神经生物学ppt课件:3离子通道和神经元的电活动.ppt
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Neuronal Electric Activities
神经元的电活动
Neuronal Electric Activities Include:
? Rest Potential (Chapter 3)
? Action Potential (Chapter 4)
? Local Potentials
- Post-Synaptic Potential
? Excitatory Post-Synaptic Potential
? Inhibitory Post-Synaptic Potential
- End-plate Potential
- Receptor Potential
Chapter 3
The Neuronal Membrane at Rest
? The CAST OF CHEMICALS
- Cytosol and Extracellular Fluid
- The Phospholipid Membrane
- Protein
? The MOVEMENT OF IONS
- Diffusion
- Electricity
? The IONIC BASIS OF RESTING MEMBRANE POTENTIAL
- Equilibrium Potential
- The Distribution of Ions Across the Membrane
- Relative Ion Permeabilities of Membrane at Rest
- The Importance of Regulating the External Potassium Concentration
? CONCLUDING REMARKS
Cytosol and Extracellular Fluid
? Water:
- Its uneven distribution of electrical charge, so H2O is a polar molecule
? Ions:
- Salt dissolves readily in water because the charged portions of the water molecule have a stronger attraction for the ions than they have for each other
The Phospholipid Membrane (磷脂膜)
The lipids of the neuronal membrane forming:
* a barrier to water-soluble ions
* a barrier to water
Protein
? These proteins provide routes for ions to cross the neuronal membrane.
? The resting and action potentials depend on special proteins that span the phospholipid bilayer.
Protein - Amino Acids
The Peptide Bond (肽键) and
a Polypeptide (多肽)
Figure 3.6 Protein Structure
Channel Proteins
? Channel protein is suspended in a phospholipid bilayer, with its
- hydrophobic (疏水的) portion inside the membrane
- hydrophilic (亲水的) ends exposed to the watery environments on either side
Two Properties of Ion Channels
? Ion selectivity (离子选择性)
- The diameter of the pore
- The nature of the R groups lining it ......
Neuronal Electric Activities
神经元的电活动
Neuronal Electric Activities Include:
? Rest Potential (Chapter 3)
? Action Potential (Chapter 4)
? Local Potentials
- Post-Synaptic Potential
? Excitatory Post-Synaptic Potential
? Inhibitory Post-Synaptic Potential
- End-plate Potential
- Receptor Potential
Chapter 3
The Neuronal Membrane at Rest
? The CAST OF CHEMICALS
- Cytosol and Extracellular Fluid
- The Phospholipid Membrane
- Protein
? The MOVEMENT OF IONS
- Diffusion
- Electricity
? The IONIC BASIS OF RESTING MEMBRANE POTENTIAL
- Equilibrium Potential
- The Distribution of Ions Across the Membrane
- Relative Ion Permeabilities of Membrane at Rest
- The Importance of Regulating the External Potassium Concentration
? CONCLUDING REMARKS
Cytosol and Extracellular Fluid
? Water:
- Its uneven distribution of electrical charge, so H2O is a polar molecule
? Ions:
- Salt dissolves readily in water because the charged portions of the water molecule have a stronger attraction for the ions than they have for each other
The Phospholipid Membrane (磷脂膜)
The lipids of the neuronal membrane forming:
* a barrier to water-soluble ions
* a barrier to water
Protein
? These proteins provide routes for ions to cross the neuronal membrane.
? The resting and action potentials depend on special proteins that span the phospholipid bilayer.
Protein - Amino Acids
The Peptide Bond (肽键) and
a Polypeptide (多肽)
Figure 3.6 Protein Structure
Channel Proteins
? Channel protein is suspended in a phospholipid bilayer, with its
- hydrophobic (疏水的) portion inside the membrane
- hydrophilic (亲水的) ends exposed to the watery environments on either side
Two Properties of Ion Channels
? Ion selectivity (离子选择性)
- The diameter of the pore
- The nature of the R groups lining it ......
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