氨基胍单盐酸盐的合成及对大鼠半乳糖性白内障预防作用的研究*
宋丹青，宋旭，蔡年生
(中国医学科学院，中国协和医科大学医药生物技术研究所，北京 100050)
[摘要] 氨基胍单盐酸盐(AG)对大鼠半乳糖性白内障的作用，AG及其双盐酸盐(2AG)对非酶糖基化反应(NEG)的作用比较进行初步探讨。实验结果表明：AG降低了白内障大鼠晶状体的平均浊度、最高浊度和混浊面积，推迟了大鼠半乳糖性白内障的发生；在1.0mmolL-1及10.0mmolL-1浓度下，2AG抑制NEG的作用稍强于AG。
[关键词] 氨基胍盐酸盐；晚期糖基化产物；半乳糖性白内障; 构型
[中图分类号] R776.1 [文献标识码] A [文章编号] 1003-3734(2001)
Preventive effect of aminoguanidine monohydrochloride
on galactose cataract in rat
Song Danqing，Song xu， Cai niansheng
(Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Peking Union Medical College, Beijing 100050，China)
[ABSTRACT] Aminoguanidine monohydrochloride(AG) and bihydrochloride(2AG) were synthesized, and their configuration were confirmed. AG reduced the mean density, highest density and opacity area of the lens and, delayed the occurrence of cataract in the rats treated with glactose. 2AG is more effective on NEG than AG with the concentration of 1.0mmol·L-1 and 10.0 mmol·L-1.
[Key Words] Aminoguanidine monohydrochloride; advanced-glycation end product; rat galactose cataract ; configuration
[参考文献]
[1] 丁力，丁宇. 治疗糖尿病并发症药物的开发与进展[J]，中国新药杂志，1999，8(10):667-670.
[2] 樊能廷，有机合成事典[M]. 北京：北京理工大学出版社，1995. 308-309.
[3] 樊能廷，有机合成事典[M]. 北京：北京理工大学出版社，1995， 595-680.
[4] Boyle DL, Blunt DS,Takemoto LJ, Confocal microcopy of cataracts from animal model systems:relevance to human nuclear cataract[J]. Exp Eye Res, 1997, 64(4): 565-572.
[5] Lacker PA, Rodriguez L, Sato S,et al. Age-dependent lens changes in galactose-fed dogs[J] Exp Eye Res, 1997, 64(3): 431-436.
[6] Stevens A. The contribution of glycation to cataract formation in diabetes[J]. J Am Optom Assoc, 1998, 69(5):19-30., 百拇医药
(中国医学科学院，中国协和医科大学医药生物技术研究所，北京 100050)
[摘要] 氨基胍单盐酸盐(AG)对大鼠半乳糖性白内障的作用，AG及其双盐酸盐(2AG)对非酶糖基化反应(NEG)的作用比较进行初步探讨。实验结果表明：AG降低了白内障大鼠晶状体的平均浊度、最高浊度和混浊面积，推迟了大鼠半乳糖性白内障的发生；在1.0mmolL-1及10.0mmolL-1浓度下，2AG抑制NEG的作用稍强于AG。
[关键词] 氨基胍盐酸盐；晚期糖基化产物；半乳糖性白内障; 构型
[中图分类号] R776.1 [文献标识码] A [文章编号] 1003-3734(2001)
Preventive effect of aminoguanidine monohydrochloride
on galactose cataract in rat
Song Danqing，Song xu， Cai niansheng
(Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Peking Union Medical College, Beijing 100050，China)
[ABSTRACT] Aminoguanidine monohydrochloride(AG) and bihydrochloride(2AG) were synthesized, and their configuration were confirmed. AG reduced the mean density, highest density and opacity area of the lens and, delayed the occurrence of cataract in the rats treated with glactose. 2AG is more effective on NEG than AG with the concentration of 1.0mmol·L-1 and 10.0 mmol·L-1.
[Key Words] Aminoguanidine monohydrochloride; advanced-glycation end product; rat galactose cataract ; configuration
[参考文献]
[1] 丁力，丁宇. 治疗糖尿病并发症药物的开发与进展[J]，中国新药杂志，1999，8(10):667-670.
[2] 樊能廷，有机合成事典[M]. 北京：北京理工大学出版社，1995. 308-309.
[3] 樊能廷，有机合成事典[M]. 北京：北京理工大学出版社，1995， 595-680.
[4] Boyle DL, Blunt DS,Takemoto LJ, Confocal microcopy of cataracts from animal model systems:relevance to human nuclear cataract[J]. Exp Eye Res, 1997, 64(4): 565-572.
[5] Lacker PA, Rodriguez L, Sato S,et al. Age-dependent lens changes in galactose-fed dogs[J] Exp Eye Res, 1997, 64(3): 431-436.
[6] Stevens A. The contribution of glycation to cataract formation in diabetes[J]. J Am Optom Assoc, 1998, 69(5):19-30., 百拇医药