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晚期糖基化终末产物(Ages)的临床病理机制及抑制Ages药物的研究
http://www.100md.com 2002年5月25日 新药网
     王真,李电东z[+@?4, 百拇医药

    (中国医学科学院 中国协和医科大学医药生物技术研究所,北京100050)z[+@?4, 百拇医药

    [摘要]在糖尿病人体内以及衰老进程中晚期糖基化终末产物(AGEs)是不断积累的,其可以通过直接或间接的方式对机体产生病理作用。本文概述的主要内容为AGEs对各种组织或细胞包括心血管组织、肾脏大脑和骨组织等的间接病理作用和机制、介导该作用的AGEs受体或其他结合蛋白,以及抑制AGEs形成和作用的药物如氨基胍等。z[+@?4, 百拇医药

    [关键词] 晚期糖基化终末产物(AGEs); AGEs受体; 氨基胍z[+@?4, 百拇医药

    Clinical Pathological Actions and Inhibitors of Advanced Glycation Endproductsz[+@?4, 百拇医药

    Wang Zhen,Li Dian Dongz[+@?4, 百拇医药

    ( Institute of Medical Biotechnology,Peking Union Medical College,Chinese Academy of Medical Science , Beijing 100050 )z[+@?4, 百拇医药

    [Abstract] Advanced glycation endproducts ( AGEs ) always accumulate in diabetic patients and senile people, which can cause pathological actions to the whole body in direct and indirect way. What is reviewed in this article includes the indirect pathological actions and mechanism of AGEs to various tissues and cells , including cardiovascular tissue,kidney,brain and bones,etc.,the AGEs receptor and other AGEs binding proteins that mediates this action and inhibitors that inhibit the formation and action of AGEs .

    [Key words] advanced glycation endproducts ( AGEs ); AGEs receptor; aminoguanidinee)cq, 百拇医药

    [作者简介] 王真(1975-),女,博士研究生。主要从事衰老机理和微生物药学研究。联系电话:(010)63165289。e)cq, 百拇医药

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