糖脉康对2型糖尿病患者尿微白蛋白排泄率作用的临床研究
迟家敏
(卫生部北京医院内分泌科，北京 100730)
[摘要] 目的：研究糖脉康对2型糖尿病患者尿微白蛋白排泄率(UAER)的作用。方法：104例2型糖尿病患者进行随机及自身对照开放研究，分为治疗组74例和对照组30例，其中治疗组口服糖脉康颗粒5g，tid，对照组30例口服安慰剂1袋，tid，疗程6个月。观察治疗前和治疗开始后3，6个月UAER的变化。结果：与治疗前比较，糖脉康可明显地降低2型糖尿病患者3个月和6个月的UAER(均P<0.01),与对照组比较，也有明显差异(分别P<0.05和P<0.01)。结论：糖脉康可降低2型糖病患者的UAER。
[关键词]糖脉康；2型糖尿病；尿微白蛋白排泄率
Clinical study on the effects of Tangmaikang upon urinary microalbumin
, http://www.100md.com
excretive rate in patients with type 2 diabetes mellitus
CHI Jia-min
(Department of Endocrinology,Beijing Hospital,Beijing 100730,China)
[Abstract] Objective:To study the effecs of Tangmaikang(a kind of Chinese traditional medicine ) on urinary microalbumin excretive rate(UAER) in patients with type 2 diabetes mellitus(DM).Methods:104 patients with type 2 DM were divided into two groups in a ramdom and open study :74 cases of treatment group given Tangmaikang 5g, and 30 cases of control group given placebo 1 packet,po,tid for 6 months.The UAER were observed at treament before and after 3th and 6th month.Results:In the treatment group,the UAER had reduced in treatment 3th and 6th month compared with the treatment before(P<0.01),there were significant difference compared with control group(P<0.05 and P<0.01,respectively).Conclusion:UAER were reduced by Tangmaikang in patients with type 2 DM.
, 百拇医药
[Key words] Tangmaikang;type 2 diabetes mellitus;urinary microalbumin excretive rate
[参考文献]
[1] World Health Organization.Diabetes Mellitus Report of WHO Study Group[R].Geneva,Swithzerland:World Health Organization.(Technical Report Series:1985,727,1-113.
[2] DCCT Research Group.The effect of intensive treatment of diabetes on thedevelopment and Progression of long-term complications in insulin-dependent diabetes mellitus[J].N Engl J Med,1993,329∶977-986.
, 百拇医药
[3] Turner RC,Cull CA,Frighi V,et al.Glycemic control with diet,sulfonylea,metformin.or insulin in patients with type 2 diabetes mellitus:progressive requirement for multiple therapies(UKPDS 49)[J].JAMA,1999,281∶2005-2012.
[4] UK Prospective Diabetes Study Group.Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes(UKPDS 33)[J]. Lancet,1998,352∶837-853.
, 百拇医药
[5] UK Prospective Diabetes Study Group.Tight blood ppressure control and risk of macrovascular and microvascular complications in type 2 diabetes(UKPDS 38)[J]. Br Med J,1998,317∶703-713.
[6] Laakso M,Lehto S,Penttila I,et al.Lipids and lipoproteins prediction coronary heart disease mortality aand morbidity in patients iwth noninsulindependent diabetes[J].Circulation,1993,88∶1421-1430.
[7] Haffner SM.Manaement of dyslipidemia in adults with diabetes.(Technical Review)[J].Diabetes Care,1998,21∶160-178.
(收稿日期：2001-07-31 修回日期：2001-08-30), http://www.100md.com
(卫生部北京医院内分泌科，北京 100730)
[摘要] 目的：研究糖脉康对2型糖尿病患者尿微白蛋白排泄率(UAER)的作用。方法：104例2型糖尿病患者进行随机及自身对照开放研究，分为治疗组74例和对照组30例，其中治疗组口服糖脉康颗粒5g，tid，对照组30例口服安慰剂1袋，tid，疗程6个月。观察治疗前和治疗开始后3，6个月UAER的变化。结果：与治疗前比较，糖脉康可明显地降低2型糖尿病患者3个月和6个月的UAER(均P<0.01),与对照组比较，也有明显差异(分别P<0.05和P<0.01)。结论：糖脉康可降低2型糖病患者的UAER。
[关键词]糖脉康；2型糖尿病；尿微白蛋白排泄率
Clinical study on the effects of Tangmaikang upon urinary microalbumin
, http://www.100md.com
excretive rate in patients with type 2 diabetes mellitus
CHI Jia-min
(Department of Endocrinology,Beijing Hospital,Beijing 100730,China)
[Abstract] Objective:To study the effecs of Tangmaikang(a kind of Chinese traditional medicine ) on urinary microalbumin excretive rate(UAER) in patients with type 2 diabetes mellitus(DM).Methods:104 patients with type 2 DM were divided into two groups in a ramdom and open study :74 cases of treatment group given Tangmaikang 5g, and 30 cases of control group given placebo 1 packet,po,tid for 6 months.The UAER were observed at treament before and after 3th and 6th month.Results:In the treatment group,the UAER had reduced in treatment 3th and 6th month compared with the treatment before(P<0.01),there were significant difference compared with control group(P<0.05 and P<0.01,respectively).Conclusion:UAER were reduced by Tangmaikang in patients with type 2 DM.
, 百拇医药
[Key words] Tangmaikang;type 2 diabetes mellitus;urinary microalbumin excretive rate
[参考文献]
[1] World Health Organization.Diabetes Mellitus Report of WHO Study Group[R].Geneva,Swithzerland:World Health Organization.(Technical Report Series:1985,727,1-113.
[2] DCCT Research Group.The effect of intensive treatment of diabetes on thedevelopment and Progression of long-term complications in insulin-dependent diabetes mellitus[J].N Engl J Med,1993,329∶977-986.
, 百拇医药
[3] Turner RC,Cull CA,Frighi V,et al.Glycemic control with diet,sulfonylea,metformin.or insulin in patients with type 2 diabetes mellitus:progressive requirement for multiple therapies(UKPDS 49)[J].JAMA,1999,281∶2005-2012.
[4] UK Prospective Diabetes Study Group.Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes(UKPDS 33)[J]. Lancet,1998,352∶837-853.
, 百拇医药
[5] UK Prospective Diabetes Study Group.Tight blood ppressure control and risk of macrovascular and microvascular complications in type 2 diabetes(UKPDS 38)[J]. Br Med J,1998,317∶703-713.
[6] Laakso M,Lehto S,Penttila I,et al.Lipids and lipoproteins prediction coronary heart disease mortality aand morbidity in patients iwth noninsulindependent diabetes[J].Circulation,1993,88∶1421-1430.
[7] Haffner SM.Manaement of dyslipidemia in adults with diabetes.(Technical Review)[J].Diabetes Care,1998,21∶160-178.
(收稿日期：2001-07-31 修回日期：2001-08-30), http://www.100md.com