毛细管气相色谱法测定氯苄律定中几种有机溶剂残留量
王志群，屠洁，倪坤仪，郝翔
(1中国药科大学分析化学教研室，南京 210009；2深圳制药厂，深圳 518029)
[摘要]目的：建立氯苄律定中几种有机溶剂残留量的测定方法。方法：采用毛细管气相色谱法，色谱柱为PEG20M石英毛细管柱(025mm×30m)，程序升温技术，用内标对比法分离测定氯苄律定中的残留溶剂。结果：建立的色谱方法对待测溶剂具有良好的分离度，在所考察的浓度范围内线性关系良好，各溶剂回收率在98.4%～105.1%，检测限1～2ng。结论：本实验建立的色谱方法灵敏、准确，适用于氯苄律定中残留有机溶剂的检测。
[关键词]氯苄律定；有机溶剂残留量；毛细管气相色谱法
[中图分类号]R972.2[文献标识码]?B[文章编号]?1003-3734(2002)01-0078-02
Capillary gas chromatographic determination of residual solvents in chrolobenzylidine
WANG Zhiqun1,TU Jie2, NI Kunyi1, HAO Xiang1
(1Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009,China;
2Shenzhen Pharmaceutical Factory, Shenzhen 518029,China)
[Abstract]Objective：To establish a method for determination of residual solvents in chrolobenzylidine. Methods:Residual solvents in chrolobenzylidine were determined by capillary gas chromatography using a PEG20M capillary column(0.25mm×30m),and 1propanol was adopted as internal standard.Results:Residual solvents were well separated in the column with a mean recovery range of 98.4%～105.1% and the detection limits of 1 to 2ng.Conclusion:A sensitive,accurate,applicable method for determination of residual solvents in chrolobenzylidine was established.
[Key words]chrolobenzyline;residual solvent;capillary gas chromatography
[作者简介]王志群(1965-)，女，讲师。主要从事分析化学及药物分析的教学和科研工作。联系电话：(025)3375891。
[参考文献]
[1]国家药典委员会.中华人民共和国药典[S].2000年版二部.北京：化学工业出版社，2000.附录64.
[2]徐新元，胡建国毛细管气相色谱法测定吡喹酮中5种有机溶剂残留量[J]药物分析杂志，1998，18(2)：114～115.
[3]Li QC,Kenneth AC，Zhuang G.A Capillary gas chromatographyic proceduce for the analysis of nine common residual solvents in waterInsoluble bulk pharmaceuticals[J]J Chromatogr Sci,1998,36(5)∶119～124.
(收稿日期：2001-04-03修回日期：2001-08-10)
, 百拇医药
(1中国药科大学分析化学教研室，南京 210009；2深圳制药厂，深圳 518029)
[摘要]目的：建立氯苄律定中几种有机溶剂残留量的测定方法。方法：采用毛细管气相色谱法，色谱柱为PEG20M石英毛细管柱(025mm×30m)，程序升温技术，用内标对比法分离测定氯苄律定中的残留溶剂。结果：建立的色谱方法对待测溶剂具有良好的分离度，在所考察的浓度范围内线性关系良好，各溶剂回收率在98.4%～105.1%，检测限1～2ng。结论：本实验建立的色谱方法灵敏、准确，适用于氯苄律定中残留有机溶剂的检测。
[关键词]氯苄律定；有机溶剂残留量；毛细管气相色谱法
[中图分类号]R972.2[文献标识码]?B[文章编号]?1003-3734(2002)01-0078-02
Capillary gas chromatographic determination of residual solvents in chrolobenzylidine
WANG Zhiqun1,TU Jie2, NI Kunyi1, HAO Xiang1
(1Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009,China;
2Shenzhen Pharmaceutical Factory, Shenzhen 518029,China)
[Abstract]Objective：To establish a method for determination of residual solvents in chrolobenzylidine. Methods:Residual solvents in chrolobenzylidine were determined by capillary gas chromatography using a PEG20M capillary column(0.25mm×30m),and 1propanol was adopted as internal standard.Results:Residual solvents were well separated in the column with a mean recovery range of 98.4%～105.1% and the detection limits of 1 to 2ng.Conclusion:A sensitive,accurate,applicable method for determination of residual solvents in chrolobenzylidine was established.
[Key words]chrolobenzyline;residual solvent;capillary gas chromatography
[作者简介]王志群(1965-)，女，讲师。主要从事分析化学及药物分析的教学和科研工作。联系电话：(025)3375891。
[参考文献]
[1]国家药典委员会.中华人民共和国药典[S].2000年版二部.北京：化学工业出版社，2000.附录64.
[2]徐新元，胡建国毛细管气相色谱法测定吡喹酮中5种有机溶剂残留量[J]药物分析杂志，1998，18(2)：114～115.
[3]Li QC,Kenneth AC，Zhuang G.A Capillary gas chromatographyic proceduce for the analysis of nine common residual solvents in waterInsoluble bulk pharmaceuticals[J]J Chromatogr Sci,1998,36(5)∶119～124.
(收稿日期：2001-04-03修回日期：2001-08-10)
, 百拇医药