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毛细管气相色谱法测定氯苄律定中几种有机溶剂残留量
http://www.100md.com 2002年5月25日 新药网
     王志群,屠洁,倪坤仪,郝翔

    (1中国药科大学分析化学教研室,南京 210009;2深圳制药厂,深圳 518029)

    [摘要]目的:建立氯苄律定中几种有机溶剂残留量的测定方法。方法:采用毛细管气相色谱法,色谱柱为PEG20M石英毛细管柱(025mm×30m),程序升温技术,用内标对比法分离测定氯苄律定中的残留溶剂。结果:建立的色谱方法对待测溶剂具有良好的分离度,在所考察的浓度范围内线性关系良好,各溶剂回收率在98.4%~105.1%,检测限1~2ng。结论:本实验建立的色谱方法灵敏、准确,适用于氯苄律定中残留有机溶剂的检测。

    [关键词]氯苄律定;有机溶剂残留量;毛细管气相色谱法

    [中图分类号]R972.2[文献标识码]?B[文章编号]?1003-3734(2002)01-0078-02

    Capillary gas chromatographic determination of residual solvents in chrolobenzylidine

    WANG Zhiqun1,TU Jie2, NI Kunyi1, HAO Xiang1

    (1Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009,China;

    2Shenzhen Pharmaceutical Factory, Shenzhen 518029,China)

    [Abstract]Objective:To establish a method for determination of residual solvents in chrolobenzylidine. Methods:Residual solvents in chrolobenzylidine were determined by capillary gas chromatography using a PEG20M capillary column(0.25mm×30m),and 1propanol was adopted as internal standard.Results:Residual solvents were well separated in the column with a mean recovery range of 98.4%~105.1% and the detection limits of 1 to 2ng.Conclusion:A sensitive,accurate,applicable method for determination of residual solvents in chrolobenzylidine was established.

    [Key words]chrolobenzyline;residual solvent;capillary gas chromatography

    [作者简介]王志群(1965-),女,讲师。主要从事分析化学及药物分析的教学和科研工作。联系电话:(025)3375891。

    [参考文献]

    [1]国家药典委员会.中华人民共和国药典[S].2000年版二部.北京:化学工业出版社,2000.附录64.

    [2]徐新元,胡建国毛细管气相色谱法测定吡喹酮中5种有机溶剂残留量[J]药物分析杂志,1998,18(2):114~115.

    [3]Li QC,Kenneth AC,Zhuang G.A Capillary gas chromatographyic proceduce for the analysis of nine common residual solvents in waterInsoluble bulk pharmaceuticals[J]J Chromatogr Sci,1998,36(5)∶119~124.

    (收稿日期:2001-04-03修回日期:2001-08-10)

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