尼莫地平输液配伍稳定性及输液器对其吸附性实验
韦曦，谭强，李慧
(1广西柳州市人民医院药剂科，柳州 545001;2桂林医学院药学系，桂林 541001)
[摘要]目的:测定2种尼莫地平输液与0.9%氯化钠注射液和5%葡萄糖注射液配伍时的性状、含量、pH值等变化以及常用输液器对尼莫地平的吸附情况。方法:用紫外分光光度法测定含量,用显微镜观察析出的微粒。结果:配伍后尼莫地平含量明显下降,进口品比国产品含量下降快,常用输液器(执行GB8368-1998标准)对尼莫地平有较强的吸附作用。结论:尼莫地平不能与葡萄糖注射液或氯化钠注射液混合输注,不能笼统使用这种常用的输液器输注尼莫地平。
[关键词]尼莫地平;配伍;微粒;紫外分光光度法;吸附
[中图分类号]R972.4[文献标识码]?B[文章编号]?1003-3734(2002)01-0080-02
The test for compatibility of nimodipine and its absorption on infusion sets
WEI Xi1,TAN Qiang2,LI Hui2
(1Department of Pharmacy Liuzhou People's Hospital,Liuzhou 545001，China;
2Department of Pharwacy,Guilin Medical College,Guilin 541001,China)
[Abstract]Objective:To determine the variation of the characteristic and content of nimodipine in injectic dextrose or injectic sodium chloride and its content absorbed by the infusion sets.Methods:The content of nimodipine was measured by UV determination,Microparticles were observed with microscope.Results:The level of nimodipine decreased evidently,and nimodipine was absorbed by infusion sets.Conclusion:Nimodipine can not be infused with injectic dextrose or sodium chloride and not to use this infusion sets
[Key words]nimodipine;compatibility;microparticles;UV determination;absorption
[作者简介]韦曦(1959-),女，副主任药师。主要从事医院药品检验工作。联系电话：(0772)2855334。
[参考文献]
[1]陈修，陈维洲，曾贵云.心血管药理学[M].北京：人民卫生出版社，1997.214.
[2]中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准.新药转正标准第七册[S].1996.70.
[3]国家基本药物领导小组.国家基本药物(西药)[M].北京：人民卫生出版社，1999.304.
(收稿日期：2001-04-23修回日期：2001-08-14)
, http://www.100md.com
(1广西柳州市人民医院药剂科，柳州 545001;2桂林医学院药学系，桂林 541001)
[摘要]目的:测定2种尼莫地平输液与0.9%氯化钠注射液和5%葡萄糖注射液配伍时的性状、含量、pH值等变化以及常用输液器对尼莫地平的吸附情况。方法:用紫外分光光度法测定含量,用显微镜观察析出的微粒。结果:配伍后尼莫地平含量明显下降,进口品比国产品含量下降快,常用输液器(执行GB8368-1998标准)对尼莫地平有较强的吸附作用。结论:尼莫地平不能与葡萄糖注射液或氯化钠注射液混合输注,不能笼统使用这种常用的输液器输注尼莫地平。
[关键词]尼莫地平;配伍;微粒;紫外分光光度法;吸附
[中图分类号]R972.4[文献标识码]?B[文章编号]?1003-3734(2002)01-0080-02
The test for compatibility of nimodipine and its absorption on infusion sets
WEI Xi1,TAN Qiang2,LI Hui2
(1Department of Pharmacy Liuzhou People's Hospital,Liuzhou 545001，China;
2Department of Pharwacy,Guilin Medical College,Guilin 541001,China)
[Abstract]Objective:To determine the variation of the characteristic and content of nimodipine in injectic dextrose or injectic sodium chloride and its content absorbed by the infusion sets.Methods:The content of nimodipine was measured by UV determination,Microparticles were observed with microscope.Results:The level of nimodipine decreased evidently,and nimodipine was absorbed by infusion sets.Conclusion:Nimodipine can not be infused with injectic dextrose or sodium chloride and not to use this infusion sets
[Key words]nimodipine;compatibility;microparticles;UV determination;absorption
[作者简介]韦曦(1959-),女，副主任药师。主要从事医院药品检验工作。联系电话：(0772)2855334。
[参考文献]
[1]陈修，陈维洲，曾贵云.心血管药理学[M].北京：人民卫生出版社，1997.214.
[2]中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准.新药转正标准第七册[S].1996.70.
[3]国家基本药物领导小组.国家基本药物(西药)[M].北京：人民卫生出版社，1999.304.
(收稿日期：2001-04-23修回日期：2001-08-14)
, http://www.100md.com