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编号:176472
抗Tac单抗的药效学、药代动力学及临床疗效
http://www.100md.com 2002年5月25日 新药网
     杨惠娣,曹惠明

    [摘要] 重组人源化单克隆抗体抗Tac单抗是一种免疫抑制剂,特异性抑制T细胞介导的免疫反应,用于减少肾移植患者发生的急性排异反应。抗Tac单抗单用或联合用药均显示较好的临床疗效及耐受性。

    [关键词] 抗Tac单抗;药效学;药代动力学;临床疗效

    Pharmacodynamic, Pharmacological and Clinical use of Zenapax

    Yang HuiDi , Chao HuiMing

    [Abstract] Zenapax, recombinant humanized IgG anti-Tac monoclonal antibody, is a new immuno-suppressive drug. The compound selectively targets activated T-lymphocytes, which are known to play a pivotal role to reduce acute organ rejection in patients receiving renal transplants. Anti-Tac monoclonal antibody displayed a satisfactory clinical effect and tolerance.

    [Key words] Zenapax ; Pharmacodynatics ; Pharmacological ; Clinical use

    [参考文献]

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    [2]Vinceni F, Lantz M,Birnbaum J,et al. A phase 1 trial of humanized.anti-interleukin 2receptor antibody in renal transplantation.Transplantation ,1997;63:33-8

    [3]Savo AM,Book BK,et al. Daclizumab rapidly saturates interleukin-2 receptor-alpha on lymph node lymphocytes in children.Transplant Proc, 1999;31:1182-3

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    [5]Nashan B, et al. Reduction of acute renal allograft rejection by daclizumab.Transplantation, 1999;67:110-5

    [6]Ekberg H, et al. 抗Tac单抗 reduces the incidence of acute rejection episodes and improves patient survival following renal transplantation. Transplantation Proc, 1999;31:267-8

    [7]Kirkman RL, et al. A phase Ι/Ц randomized double-blind placebo-controlled study of 抗Tac单抗 in combination with Cellcept, Neoral and steroids, Nutley, USA: Hoffman La Roche Inc,1998.

    [8]Vincenti F, et al. Can antibody prophlaxis allow sparing of other immunosuppressives? Transplant Proc, 1999;31:1246-8

    [9]Nevin T, et al. Daclizumab in pediatric renal allografts: final data. Transplantation ,1999;67:s124

    [10]抗Tac单抗 product monmgraph. Basel, Switzerland:F. Hoffman-La Roche(Basel),1997., http://www.100md.com