治疗男性勃起功能障碍的新型药物——磷酸二酯酶抑制剂V研究进展
王佳宁，吴松
( 中国医学科学院 中国协和医科大学 药物研究所开发室， 北京 100050 )
[摘要] 男性勃起功能障碍(ED)， 是临床上较为常见的一种性功能障碍疾病。磷酸二酯酶V(PDE5)是存在于平滑肌、血小板等组织中一种有特定结构和功能的磷酸二酯酶亚型。 口服PDE5抑制剂使环磷酸鸟苷酸水平升高，促使血管平滑肌扩张，达到治疗男性ED的作用。 目前除了Sildenafil以外，还有一些结构不同的化合物具有PED5抑制作用。 他们有可能成为更具疗效及选择性的ED治疗药物。 本文对磷酸二酯酶V抑制剂研究进展作一概述
[关键词] 男性勃起功能障碍； 磷酸二酯酶V； 先导化合物
Recent Research Progress in Inhibitors of PhosphodiesteraseType5,a New Kind of Anti-Male Erectile DysfunctionAgent
Wang Jianing , Wu Song
(Institute of Materia Medica, Peking Union Medical College,Chinese Academy of Medical Science, Beijing 100050, P.R.China)
[Abstract] Male erectile dysfunction (ED) is a common clinical sexual dysfunction. Phosphodiesterases is one of phosphodiesterases families that are particularly abundant in smooth muscle and blood platelet. Taking the PDE5 inhibitors raises the level of cAMP, induces dilation of smooth muscle, so that cures the male ED. Besides the Sildenafil, there are also some other kinds of compounds that can inhibit PDE5. Maybe they will become selective and effective anti-impotence drugs. In this paper, research progress in PDE5 inhibitors was reviewed.
[Key Words] Male Erectile Dysfunction; Phosphodiesterase Type 5; leading Compound .
, 百拇医药
( 中国医学科学院 中国协和医科大学 药物研究所开发室， 北京 100050 )
[摘要] 男性勃起功能障碍(ED)， 是临床上较为常见的一种性功能障碍疾病。磷酸二酯酶V(PDE5)是存在于平滑肌、血小板等组织中一种有特定结构和功能的磷酸二酯酶亚型。 口服PDE5抑制剂使环磷酸鸟苷酸水平升高，促使血管平滑肌扩张，达到治疗男性ED的作用。 目前除了Sildenafil以外，还有一些结构不同的化合物具有PED5抑制作用。 他们有可能成为更具疗效及选择性的ED治疗药物。 本文对磷酸二酯酶V抑制剂研究进展作一概述
[关键词] 男性勃起功能障碍； 磷酸二酯酶V； 先导化合物
Recent Research Progress in Inhibitors of PhosphodiesteraseType5,a New Kind of Anti-Male Erectile DysfunctionAgent
Wang Jianing , Wu Song
(Institute of Materia Medica, Peking Union Medical College,Chinese Academy of Medical Science, Beijing 100050, P.R.China)
[Abstract] Male erectile dysfunction (ED) is a common clinical sexual dysfunction. Phosphodiesterases is one of phosphodiesterases families that are particularly abundant in smooth muscle and blood platelet. Taking the PDE5 inhibitors raises the level of cAMP, induces dilation of smooth muscle, so that cures the male ED. Besides the Sildenafil, there are also some other kinds of compounds that can inhibit PDE5. Maybe they will become selective and effective anti-impotence drugs. In this paper, research progress in PDE5 inhibitors was reviewed.
[Key Words] Male Erectile Dysfunction; Phosphodiesterase Type 5; leading Compound .
, 百拇医药