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相思子毒素的分子特点及其在临床中的应用前景
http://www.100md.com 2002年5月25日 新药网
     李丽琴,郑晓军,史瑞雪,陈乐贵,林福生

    [摘要] 相思子毒素是从豆科植物(Abrus Precatorius L.)种子中分离的一种细胞毒性蛋白。它由A,B两条链组成,由一个二硫键相联,B链具有半乳糖凝集活性,可与细胞膜上受体结合,帮助A链进入细胞内,A链进入细胞催化失活60S核糖体亚基,从而使细胞蛋白合成被抑制。本文综述了有关相思子毒素的分子结构特点,毒性机制和在临床中的应用前景。

    [关键词] 相思子毒素; 结构特点; 免疫毒素 ; 临床应用

    MOLECULAR CHARACTERISTICS AND CLINICAL

    APPLICATION PROSPECT OF ABRIN

    Li liqin , Zheng xiaojun ,Shi ruixue, Chen legui,Lin fusheng
, 百拇医药
    ( Pharmaceutical Chemistry Institute of Beijing BeiJing 102205)

    [Abstract] Abrin is one of the potent toxins isolated from the beans of plant Abrus precatorius.The toxic protein consists of two disulfide-bonded subunits,the A and B chains.The B chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis.After entering the cells,the A chain catalytically inactivates 60S ribosomal subunits by removing adenine position 4324 of 28S r–RNA,and thereby inhibits protein biosynthesis. This literature on abrin has been reviewed with respect to:(i)the abrin structural characteristics, (ii) action mechanism of causing poison of abrin,(iii) application prospect in clinical of abrin.
, http://www.100md.com
    [Key Words] abrin;structural characteristics;immunotoxin;clinical application

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