急性心肌梗死静脉溶栓治疗(2)
二、 溶栓时间窗
从多项临床试验的数据中描出入选溶栓时间与死亡率下降的曲线。可见到50%以上的死亡率下降发生在症状发作后第一个黄金小时(golden first hour)。此后死亡率下降的得益降到平台期,约下降25%直到发病后12小时。12小时后,用溶栓疗法未能证明得到显著的存活益处。图中试验缩写为:AIMS=Anistreplase Intervention Mortality Study, ASSET=Anglo-Scandinavian Study of Early Thrombolysis, EMERAS=Estudio Multicentrico Estreptoquinasa Studio della Streptochinasi nell' Infartl Miocardico, ISIS-2=Second International Study of Infarct Survival, LATE=Late Assessment of Thrombolytic Efficacy, MITI=Myocardial Infarction and Triage Intervention Project, (来自Lincoff AM, Topol EJ. The illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation. 1993; 87: 1792~1805), http://www.100md.com(李海燕)
从多项临床试验的数据中描出入选溶栓时间与死亡率下降的曲线。可见到50%以上的死亡率下降发生在症状发作后第一个黄金小时(golden first hour)。此后死亡率下降的得益降到平台期,约下降25%直到发病后12小时。12小时后,用溶栓疗法未能证明得到显著的存活益处。图中试验缩写为:AIMS=Anistreplase Intervention Mortality Study, ASSET=Anglo-Scandinavian Study of Early Thrombolysis, EMERAS=Estudio Multicentrico Estreptoquinasa Studio della Streptochinasi nell' Infartl Miocardico, ISIS-2=Second International Study of Infarct Survival, LATE=Late Assessment of Thrombolytic Efficacy, MITI=Myocardial Infarction and Triage Intervention Project, (来自Lincoff AM, Topol EJ. The illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation. 1993; 87: 1792~1805), http://www.100md.com(李海燕)