甲状腺疾病患者促甲状腺素受体膜外区基因突变的研究(4)
of "autoimmune TSH receptor disease". Endocr J, 1994, 41: 1-11.
3.Van Sande J, Parma J, Tonacchera M, et al. Somatic and germline mutation of the TSH receptor gene in thyroid disease. J Clin Endocrinol Metab, 1995, 80: 2577-2585.
4.Nagayama Y, Kaufman KD, Steo P, et al. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun, 1989, 165: 1184-1190.
, 百拇医药
5.Misrahi M, Loosfelt H, Atger M, et al. Cloning, sequencing and expression of human thyyotropin receptor. Biochem Biophys Res Commun, 1990, 166:394-403.
6.McIntosh R, Watson P, Weetman A. Somatic hypermutation in autoimmune thyroid disease. Immuno Rev, 1998, 162: 219-231.
7.Bohr UR, Behr M, Loos U. A heritable point mutation in an extracellular domain of the TSH receptor involved in the interaction with Graves' immunoglobulins. Biochem Biophys Acta, 1993, 1216: 504-508.
, 百拇医药
8.Loos U, Hagner S, Bohr UR, et al. Enhanced cAMP accumulation by the human thyrotropin receptor variant with the Pro52Thr substitution in the extracellular domain. Eur J Biochem, 1995, 232: 62-65.
9.Cuddihy RM, Schaid DS, Bahn RS. Multivariate analysis of HLA loci in conjunction with a thyrotropin receptor codon 52 polymorphism in conferring risk of Graves' disease. Thyroid, 1996, 6: 261-265.
10.Sunthornthevarakul T, Hayashi Y, Refetoff S. Polymorphism of a variant human thyrotropin receptor (hTSHR) gene. Thyroid, 1994, 4: 147-149.
, http://www.100md.com
11.Watson PF, French A, Pickerill AP, et al. Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease. J Clin Endocrinol Metab, 1995, 80: 1032-1035.
12.Fuhrer D, Kubisch C, Scheibler U, et al. The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules. Thyroid, 1998, 8:997-1001.
13.Krohn K, Fuhrer D, Holzapfel HP, et al. Clonal oringin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations. J Clin Endocrinol Metab, 1998, 83: 130-134.
, http://www.100md.com
14.Tonacchera M, Chiovato L, Pinchera A, et al. Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. J Clin Endocrinol Metab, 1998, 83: 492-498.
15.Tonacchera M, Vitti P, Agretti P. Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms. J Clin Endocrinol Metab, 1999, 84: 4155-4158., http://www.100md.com(张遵城 方佩华 周津东)
3.Van Sande J, Parma J, Tonacchera M, et al. Somatic and germline mutation of the TSH receptor gene in thyroid disease. J Clin Endocrinol Metab, 1995, 80: 2577-2585.
4.Nagayama Y, Kaufman KD, Steo P, et al. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun, 1989, 165: 1184-1190.
, 百拇医药
5.Misrahi M, Loosfelt H, Atger M, et al. Cloning, sequencing and expression of human thyyotropin receptor. Biochem Biophys Res Commun, 1990, 166:394-403.
6.McIntosh R, Watson P, Weetman A. Somatic hypermutation in autoimmune thyroid disease. Immuno Rev, 1998, 162: 219-231.
7.Bohr UR, Behr M, Loos U. A heritable point mutation in an extracellular domain of the TSH receptor involved in the interaction with Graves' immunoglobulins. Biochem Biophys Acta, 1993, 1216: 504-508.
, 百拇医药
8.Loos U, Hagner S, Bohr UR, et al. Enhanced cAMP accumulation by the human thyrotropin receptor variant with the Pro52Thr substitution in the extracellular domain. Eur J Biochem, 1995, 232: 62-65.
9.Cuddihy RM, Schaid DS, Bahn RS. Multivariate analysis of HLA loci in conjunction with a thyrotropin receptor codon 52 polymorphism in conferring risk of Graves' disease. Thyroid, 1996, 6: 261-265.
10.Sunthornthevarakul T, Hayashi Y, Refetoff S. Polymorphism of a variant human thyrotropin receptor (hTSHR) gene. Thyroid, 1994, 4: 147-149.
, http://www.100md.com
11.Watson PF, French A, Pickerill AP, et al. Lack of association between a polymorphism in the coding region of the thyrotropin receptor gene and Graves' disease. J Clin Endocrinol Metab, 1995, 80: 1032-1035.
12.Fuhrer D, Kubisch C, Scheibler U, et al. The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules. Thyroid, 1998, 8:997-1001.
13.Krohn K, Fuhrer D, Holzapfel HP, et al. Clonal oringin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations. J Clin Endocrinol Metab, 1998, 83: 130-134.
, http://www.100md.com
14.Tonacchera M, Chiovato L, Pinchera A, et al. Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. J Clin Endocrinol Metab, 1998, 83: 492-498.
15.Tonacchera M, Vitti P, Agretti P. Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms. J Clin Endocrinol Metab, 1999, 84: 4155-4158., http://www.100md.com(张遵城 方佩华 周津东)