老年患者使用NSAID(非甾体抗炎药)治疗骨关节炎(OA)的性别差异
背景：NSAID是目前治疗OA使用最广泛的处方药物。但人们对OA患者使用该类药物不同性别差异知之甚少。
目的：观察老年OA患者(年龄大于65岁)使用NSAID的性别差异
方法：1997年全州处方药计划与健康生命质量(HRQOL)观察且均被诊断为OA成员11,298名。使用NSAID药物观察超过两年。
结果：大约三分之一参加者至少使用一种NSAID药物。与男性患者比较，女性患者更易于接受NSAID药物；女性NSAID给药频率高于男性，且对COX-2选择性程度较高。性别差异的结论来自于人口因素、 HRQOL和胃肠道危险因素不同性别对照统计分析的结果。
结论：本项研究表明老年OA患者使用NSAID存在明显差异，并且这些差别可独立于胃肠道不良反应和患者自述症状。有关OA不同性别患者使用NSAID类药物差异显著的原因还有待进一步研究与总结，包括对症治疗质量的影响。
BACKGROUND: Nonsteroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed medications for the treatment of osteoarthritis (OA). Little is known about whether there are important gender differences in NSAID use among patients with OA.
OBJECTIVE: To examine gender differences in patterns of NSAID use among older adults (>65 y) with OA.
METHODS: Subjects (n = 11298) were members of a statewide prescription drug plan who responded to a health-related quality-of-life (HRQOL) survey in 1997 and had a physician diagnosis of OA. Gender differences in patterns of NSAID use were examined over a 2-year period.
RESULTS: Approximately one-third of the participants filled at least 1 NSAID prescription during the study. Women were significantly more likely to be prescribed an NSAID than men (37% vs. 30%), had a greater total days' supply of NSAIDs, and were more frequently prescribed NSAIDs with greater degrees of cyclooxygenase-2 selectivity. These gender differences persisted in statistical analyses controlling for demographic factors, HRQOL, and gastrointestinal (GI) risk factors.
CONCLUSIONS: Results of this study showed significant gender differences in patterns of NSAID use, and these differences were independent of the risk for GI adverse effects and self-reported symptoms. Further research is needed to examine reasons for these gender variations, as well as their impact on the quality of symptom management.
(风雪来 译), 百拇医药(Kelli L Dominick, Frank M Aher)
目的：观察老年OA患者(年龄大于65岁)使用NSAID的性别差异
方法：1997年全州处方药计划与健康生命质量(HRQOL)观察且均被诊断为OA成员11,298名。使用NSAID药物观察超过两年。
结果：大约三分之一参加者至少使用一种NSAID药物。与男性患者比较，女性患者更易于接受NSAID药物；女性NSAID给药频率高于男性，且对COX-2选择性程度较高。性别差异的结论来自于人口因素、 HRQOL和胃肠道危险因素不同性别对照统计分析的结果。
结论：本项研究表明老年OA患者使用NSAID存在明显差异，并且这些差别可独立于胃肠道不良反应和患者自述症状。有关OA不同性别患者使用NSAID类药物差异显著的原因还有待进一步研究与总结，包括对症治疗质量的影响。
BACKGROUND: Nonsteroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed medications for the treatment of osteoarthritis (OA). Little is known about whether there are important gender differences in NSAID use among patients with OA.
OBJECTIVE: To examine gender differences in patterns of NSAID use among older adults (>65 y) with OA.
METHODS: Subjects (n = 11298) were members of a statewide prescription drug plan who responded to a health-related quality-of-life (HRQOL) survey in 1997 and had a physician diagnosis of OA. Gender differences in patterns of NSAID use were examined over a 2-year period.
RESULTS: Approximately one-third of the participants filled at least 1 NSAID prescription during the study. Women were significantly more likely to be prescribed an NSAID than men (37% vs. 30%), had a greater total days' supply of NSAIDs, and were more frequently prescribed NSAIDs with greater degrees of cyclooxygenase-2 selectivity. These gender differences persisted in statistical analyses controlling for demographic factors, HRQOL, and gastrointestinal (GI) risk factors.
CONCLUSIONS: Results of this study showed significant gender differences in patterns of NSAID use, and these differences were independent of the risk for GI adverse effects and self-reported symptoms. Further research is needed to examine reasons for these gender variations, as well as their impact on the quality of symptom management.
(风雪来 译), 百拇医药(Kelli L Dominick, Frank M Aher)