一种新型的T型钙通道在冠状动脉功能中起关键作用
编者按：这个发现重大意义在于观察到α1H T-type calcium channel在冠状动脉功能中的至关重要作用，为缺血性心脏的治疗和预防，以及其遗传学背景提供了重要的参考。
Abnormal Coronary Function in Mice Deficient in
1H T-type Ca2+ Channels
Science Nov 21 2003: 1416-1418.
Chien-Chang Chen,1,2 Kathryn G. Lamping,4,5,7 Daniel W. Nuno,4,5,7 Rita Barresi,1,2 Sally J. Prouty,1,2 Julie L. Lavoie,4 Leanne L. Cribbs,8 Sarah K. England,2 Curt D. Sigmund,4 Robert M. Weiss,4,7 Roger A. Williamson,6 Joseph A. Hill,9 Kevin P. Campbell1,2,3*
, http://www.100md.com
Calcium ion (Ca2+) influx through voltage-gated Ca2+ channels is important for the regulation of vascular tone. Activation of L-type Ca2+ channels initiates muscle contraction; however, the role of T-type Ca2+ channels (T-channels) is not clear. We show that mice deficient in the
1H T-type Ca2+ channel (13.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from 13.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through 1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries.
, 百拇医药
1 Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA.
2 Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
3 Department of Neurology, University of Iowa, Iowa City, IA 52242, USA.
4 Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
, 百拇医药
5 Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA.
6 Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, USA.
7 Veterans Administration Medical Center, Iowa City, IA 52242, USA.
8 Cardiovascular Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
, 百拇医药
9 Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
* To whom correspondence should be addressed. E-mail: kevin-campbell@uiowa.edu
Abstract of this Article
PDF Version of this Article, http://www.100md.com
Abnormal Coronary Function in Mice Deficient in
1H T-type Ca2+ ChannelsScience Nov 21 2003: 1416-1418.
Chien-Chang Chen,1,2 Kathryn G. Lamping,4,5,7 Daniel W. Nuno,4,5,7 Rita Barresi,1,2 Sally J. Prouty,1,2 Julie L. Lavoie,4 Leanne L. Cribbs,8 Sarah K. England,2 Curt D. Sigmund,4 Robert M. Weiss,4,7 Roger A. Williamson,6 Joseph A. Hill,9 Kevin P. Campbell1,2,3*
, http://www.100md.com
Calcium ion (Ca2+) influx through voltage-gated Ca2+ channels is important for the regulation of vascular tone. Activation of L-type Ca2+ channels initiates muscle contraction; however, the role of T-type Ca2+ channels (T-channels) is not clear. We show that mice deficient in the
1H T-type Ca2+ channel (13.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from 13.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through 1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries. , 百拇医药
1 Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA.
2 Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
3 Department of Neurology, University of Iowa, Iowa City, IA 52242, USA.
4 Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
, 百拇医药
5 Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA.
6 Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, USA.
7 Veterans Administration Medical Center, Iowa City, IA 52242, USA.
8 Cardiovascular Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
, 百拇医药
9 Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
* To whom correspondence should be addressed. E-mail: kevin-campbell@uiowa.edu
Abstract of this Article
PDF Version of this Article, http://www.100md.com