单层芯渗透泵片用于水不溶性药物的控制释放
单层芯渗透泵片|水不溶性药物|硝苯吡啶|控制释放,关键词：
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刘龙孝；徐清；姜吉善；李钟文；李海邦 浙江大学校医院 浙江杭州310027；全北大学高分子工学科 韩国全州561-756；韩国化学研究院生物材料研究室 韩国大田305-600 药学学报 2003 12
关键词：单层芯渗透泵片；水不溶性药物；硝苯吡啶；控制释放
Aim To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Methods Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Results Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Conclusion Unitary-core osmotic pump tablet is very easy in preparation and...
关键词：单层芯渗透泵片；水不溶性药物；硝苯吡啶；控制释放
Aim To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Methods Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Results Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Conclusion Unitary-core osmotic pump tablet is very easy in preparation and...
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