温度敏感原位凝胶中药物的扩散行为
温度敏感凝胶|泊洛沙姆|扩散,关键词：
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魏刚；陆伟跃；郑俊民 复旦大学药学院 上海200032；沈阳药科大学药学院 辽宁沈阳110016 药学学报 2004 3
关键词：温度敏感凝胶；泊洛沙姆；扩散
Aim To study the diffusion behaviors of drugs in thermosensitive in situ gels, and provide valuable information for designing such delivery systems. Methods A free diffusion model was used to evaluate the effects of concentration, the property of drugs, as well as the gel compositions on the diffusivity of drugs. Results Drug transport through the aqueous channels of the gel followed Fickian mechanism, and no significant influence on the diffusivity was observed when the drug concentration was lower...
关键词：温度敏感凝胶；泊洛沙姆；扩散
Aim To study the diffusion behaviors of drugs in thermosensitive in situ gels, and provide valuable information for designing such delivery systems. Methods A free diffusion model was used to evaluate the effects of concentration, the property of drugs, as well as the gel compositions on the diffusivity of drugs. Results Drug transport through the aqueous channels of the gel followed Fickian mechanism, and no significant influence on the diffusivity was observed when the drug concentration was lower...
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