郝伟 李风翔 2004-8-8 15:19:56 中国神经免疫学和神经病学杂志 2000年第1期第7卷 论著

    摘要：目的 探讨多发性硬化合并周围神经损害的临床特点和发病机制。方法 对2例多发性硬化患者进行临床观察及电生理检查，并作文献复习。结果 2例患者均有下运动神经元异常表现，膝、跟腱反射消失，神经传导速度减慢，电生理检查提示病变既没有损害前角细胞，也没有累及周围神经的髓内根，可能是周围神经受影响。结论 中枢神经系统和周围神经系统联合受累的机制可能在于自身免疫反应，有一种类似髓鞘碱性蛋白的抗原，由于它在中枢神经系统占优势，免疫反应造成神经系统受损程度不同，或者中枢神经系统损害严重，导致血脑屏障及血神经屏障受损，最后导致周围神经脱髓鞘和轴索变性。

    中图分类号：R744.5 文献标识码：A

    文章编号：1006-2963(2000)01-042-03

    Peripheral Nerve Abnormalities in Multiple Sclerosis

    HAO Wei，LI Feng-xiang

    (Department of Neurology, Fifth Hospital, Baoding 071051, China)

    ABSTRACT：Objective To study the clinical characteristies and mechanisms of peripheral neuropathy in multiple sclerosis.Methods It was to observe clinical signs and electrophysiologic testing of two patients with multiple sclerosis and combined with reviewing the literature.Results The two patients with multiple sclerosis showed signs of lower motor neuron abnormalities, The knee and ankle muscle stretch reflexes of the two instance are lost, and peripheral never conduction was slowed. The electrodiagnostic and multiple sclerosis at autopsy indicated that lessions were involving neither the anterior horn nor entirely ventral exit Zones peripheries, It mighr affect the peripheral nerves, As if multiple sclerosis Combined with acute inflammatory demylinating polyradiculoneuropathies.Conclusion The possibility of the mechanisms that assosiated central nervous system with peripheral nervous system involved were autoimmunity. There might be an antigen such as mylin basic protein. was predominant over central nervous system, So central nervous system and peripheral nervous system were involved differently, and central nervous system was damaged severely, It induced the lesion of the blood-brain and blood-nerve barriers. Finally peripheral nerve demylination and axonal degeneration had occured. ......