张琳 张璐 王素琴 中华实验和临床病毒学杂志 1999年第1期第0卷 论著

    【摘要】 目的 探讨肾综合征出血热(HFRS)的发病机理。方法 2～3天的近交系Balb/C乳鼠，脑内接种早期HFRS重症患者软腭粘膜出血点组织悬液，用套式聚合酶链式反应检测乳鼠脑、肺及肾组织中的HFRS病毒RNA。结果 接种乳鼠发病死亡，剖检显示，发病乳鼠各器官呈现明显微血管系统和实质组织病变，乳鼠脑、肺及肾组织中HFRS病毒RNA阳性。结论 早期HFRS患者软腭粘膜出血点组织中含有HFRS病毒。

    The pathogenicity of HFRS patient′s soft palate mucosa to suckling mice

    ZHANG Lin, ZHANG Lu, WANG Suqin.

    The First Military Medical University, Guangzhou 510515

    【Abstract】 Objective To expiore the pathogenic mechanism of hemorrhagic fever with renal syndrome(HFRS).Methods 2-3 days old inbred Balb/C suckling mice were inoculated intracerebrally with tissue suspension of soft parate petechia of HFRS patients and the HFRS virus RNA was tested in brain, lung and kidney tissues of sucking mice by nested PCR.Results Some of the mice developed acute disease and died. The autopsy analysis indicated that these mice showed pathological changes in system microvascular and parenchymatous tissues. HFRS virus RNA was detected in their brains, lungs and kidney tissues.Conclusions These results indicate that HFRS virus exists in the tissue of petechial hemorrlngic spots on soft palate petechia of HFRS patients. ......