经皮二尖瓣球囊成形术引起二尖瓣反流的组织力学机理探讨(摘要)
作者：吴照芝 李华泰 杨平生
单位：江西省南昌市，江西省人民医院 心内科(330006) 吴照芝 李华泰；南昌大学 杨平生(第二作者)
关键词：
目的 目的：探讨经皮二尖瓣球囊成形术(PBMV)的组织力学机理和分级次扩张防止二尖瓣反流(MR)的组织力学依据。
方法：20个硅胶二尖瓣模型，12个新鲜人体病变二尖瓣随机分组进行体外球囊扩张术力学实验研究，建立了PBMV的力学模型。
结果：①人体二尖瓣受球囊扩张后发生瞬态弹性变形和粘性流动，具有粘弹性体的结构特征和力学规律。②力学模型显示PBMV疗效和MR的发生与二尖瓣的几何构形，扩张球囊张力，扩张速度与扩张持续时间，组织结构瓣膜变形，撕裂与自动止裂等一系列组织力学要素相关。③力学模型较好地解释了为什么分级次扩张在疗效和防止MR方面比一级次扩张术更好。
结论：作者提出了一个PBMV的组织力学模型；该模型显示PBMV的疗效和MR的发生与一系列组织力学因素有关，从而进一步说明了分级次PBMV能提高疗效防止MR。
Study on the Biomechanics of Mitral Regurgitation after Percutaneous Balloon Mitral Valvuloplasty (Abstract)
Department of Cardiology, People′s Hospital of Jiangxi, Nanchang (330006), Jiangxi
Wu Zhaozhi, Yang Pingsheng, Li Huatai.
Objective: To study the Biomechanics of mitral regurgitation (MR) after percutaneous balloon mitral valvulopasty (PBMV) and gradual balloon mitral valvuloplasty (GBMV).
Methods: Contrastive mechanical simulated tests have been conducted with PBMV and GBMV on 20 silica gel mitral valve models and 12 human diseased mitral valves. Thus a mechanical model of PBMV was established.
Results: ① Under the load of PBMV, human mitral valve deformed according to constitutive equation for viscoelastic body. ② The mechanical model showed that the curative effect of PBMV and occurrence of MR depend on many biomechanical factors such as valve geometry dilated balloon tension, velocity and duration of dilatation, tissue constitutive relation, valve deformation, crack initiation, and crack stop. ③ The model explained why the curative effect with GBMV was better than that with PBMV.
Conclusion: A biomechanical model was proposed for PBMV. The model shows that the curative effect depends on a series of biomechanical factors. The GBMV is a valuable method of effectual dilatation and prevents MR after PBMV., http://www.100md.com
单位：江西省南昌市，江西省人民医院 心内科(330006) 吴照芝 李华泰；南昌大学 杨平生(第二作者)
关键词：
目的 目的：探讨经皮二尖瓣球囊成形术(PBMV)的组织力学机理和分级次扩张防止二尖瓣反流(MR)的组织力学依据。
方法：20个硅胶二尖瓣模型，12个新鲜人体病变二尖瓣随机分组进行体外球囊扩张术力学实验研究，建立了PBMV的力学模型。
结果：①人体二尖瓣受球囊扩张后发生瞬态弹性变形和粘性流动，具有粘弹性体的结构特征和力学规律。②力学模型显示PBMV疗效和MR的发生与二尖瓣的几何构形，扩张球囊张力，扩张速度与扩张持续时间，组织结构瓣膜变形，撕裂与自动止裂等一系列组织力学要素相关。③力学模型较好地解释了为什么分级次扩张在疗效和防止MR方面比一级次扩张术更好。
结论：作者提出了一个PBMV的组织力学模型；该模型显示PBMV的疗效和MR的发生与一系列组织力学因素有关，从而进一步说明了分级次PBMV能提高疗效防止MR。
Study on the Biomechanics of Mitral Regurgitation after Percutaneous Balloon Mitral Valvuloplasty (Abstract)
Department of Cardiology, People′s Hospital of Jiangxi, Nanchang (330006), Jiangxi
Wu Zhaozhi, Yang Pingsheng, Li Huatai.
Objective: To study the Biomechanics of mitral regurgitation (MR) after percutaneous balloon mitral valvulopasty (PBMV) and gradual balloon mitral valvuloplasty (GBMV).
Methods: Contrastive mechanical simulated tests have been conducted with PBMV and GBMV on 20 silica gel mitral valve models and 12 human diseased mitral valves. Thus a mechanical model of PBMV was established.
Results: ① Under the load of PBMV, human mitral valve deformed according to constitutive equation for viscoelastic body. ② The mechanical model showed that the curative effect of PBMV and occurrence of MR depend on many biomechanical factors such as valve geometry dilated balloon tension, velocity and duration of dilatation, tissue constitutive relation, valve deformation, crack initiation, and crack stop. ③ The model explained why the curative effect with GBMV was better than that with PBMV.
Conclusion: A biomechanical model was proposed for PBMV. The model shows that the curative effect depends on a series of biomechanical factors. The GBMV is a valuable method of effectual dilatation and prevents MR after PBMV., http://www.100md.com