CardioSEAL和Amplatzer方法介入性治疗心房间隔缺损(摘要)
作者：李志忠 韩玲 金梅 吴邦骏 张桂珍
单位：北京市，心肺血管疾病研究所 首都医科大学附属北京安贞医院 导管室(100029)
关键词：
中国循环杂志99zk102 目的：探讨CardioSEAL和Amplatzer方法经导管治疗心房间隔缺损并对其疗效进行评价。
方法：20例患者，年龄30.00±14.35(9～49)岁，体重57.91±12.23(42～78)kg,肺循环血流量/体循环血流量(QP/QS)为2.73±1.98(1.25±5.86)。在透视和食管超声心动图引导下，经皮穿刺股静脉置入CardioSEAL和Amplatzer封堵器关闭心房间隔缺损。术后24小时、3月、6月和1年行经胸超声心动图、心电图、X线胸片检查，评价其疗效及并发症。
, 百拇医药 结果：全组技术成功率100%。术后即刻QP/QS为1.09±0.08(1.00～1.25)。CardioSEAL法6例术后24小时超声心动图示3例有极少量残余分流，1年后该分流消失；1例有2个孔，分别置入23、28 mm 2个CardioSEAL封堵器；1例于术后6月超声心动图发现1条弹性臂断裂但未造成任何影响，仍在随访。Amplatzer法14例，其中1例有3个孔置入1个直径30 mm的Amplatzer封堵器，该14例术后即刻均完全堵闭，无残余分流。随访均无再通或装置移位。
结论：经导管关闭心房间隔缺损操作简便、成功率高、疗效可靠，但Amplatzer方法适用范围更广，术后即刻成功率更高，二者远期疗效尚需进一步观察。
Percutaneous Closure of Atrial Septal Defect Using CardioSEAL and Amplatzer Occluder (Abstract)
, 百拇医药
Catheterization Laboratory, Institute of Beijing Heart, Lung and Blood Vessel Disease, An
Zhen Hospital, Capital Medical University, Beijing (100029)
Li Zhizhong, Han Lingjin, Jin Mei, et al.
Objective: To evaluate the effect and results of transcatheter closure of secundum atrial septal defect (ASD) using CardioSEAL and Amplatzer occluder.
Methods: Twenty patients of mean age 30.00±14.35 (ranged from 9～49) years and weight 57.91±12.23 (ranged from 42～78) kg were evaluated. Guided by fluoroscopy and transesophageal echocardiography, ASD was occluded using CardioSEAL or Amplatzer device through percutaneous procedure. The transthoracic echocardiography ECG and chest film were performed 24 hours, 3 months, 6 months and 1 year after the procedure to evaluate its therapeutic effect and complications.
, 百拇医药
Results: The success rate was 100%, the QP∶QS was 1.09±0.08 (1.00～1.25). The CardioSEAL devices were performed for 6 cases, a very little residual shunt was found in each of 3 cases 24 hours after the procedure, but it was disappeared 1 year later. Two CardioSEAL devices of 23 and 28 mm were used in one patient with two holes. One arm ruptured at 6 months′ follow-up in 1 case without any apparent influence, but still in follow-up. The defect were completely and instantly occluded after the procedure using Amplatzer occluder in 14 cases, one of them was found 3 holes and closed with an Amplatzer occluder of 30 mm. No residual shunt or devices displacement or recanalization was found in follow-up.
Conclusion: Transcatheter closure of ASD is a simple and convenient method of high success rate and reliable curative effect, but the indication of Amplatzer method is much wider and the instant success rate after the procedure is much higher, the remote effect of both methods needs further observation., 百拇医药
单位：北京市，心肺血管疾病研究所 首都医科大学附属北京安贞医院 导管室(100029)
关键词：
中国循环杂志99zk102 目的：探讨CardioSEAL和Amplatzer方法经导管治疗心房间隔缺损并对其疗效进行评价。
方法：20例患者，年龄30.00±14.35(9～49)岁，体重57.91±12.23(42～78)kg,肺循环血流量/体循环血流量(QP/QS)为2.73±1.98(1.25±5.86)。在透视和食管超声心动图引导下，经皮穿刺股静脉置入CardioSEAL和Amplatzer封堵器关闭心房间隔缺损。术后24小时、3月、6月和1年行经胸超声心动图、心电图、X线胸片检查，评价其疗效及并发症。
, 百拇医药 结果：全组技术成功率100%。术后即刻QP/QS为1.09±0.08(1.00～1.25)。CardioSEAL法6例术后24小时超声心动图示3例有极少量残余分流，1年后该分流消失；1例有2个孔，分别置入23、28 mm 2个CardioSEAL封堵器；1例于术后6月超声心动图发现1条弹性臂断裂但未造成任何影响，仍在随访。Amplatzer法14例，其中1例有3个孔置入1个直径30 mm的Amplatzer封堵器，该14例术后即刻均完全堵闭，无残余分流。随访均无再通或装置移位。
结论：经导管关闭心房间隔缺损操作简便、成功率高、疗效可靠，但Amplatzer方法适用范围更广，术后即刻成功率更高，二者远期疗效尚需进一步观察。
Percutaneous Closure of Atrial Septal Defect Using CardioSEAL and Amplatzer Occluder (Abstract)
, 百拇医药
Catheterization Laboratory, Institute of Beijing Heart, Lung and Blood Vessel Disease, An
Zhen Hospital, Capital Medical University, Beijing (100029)
Li Zhizhong, Han Lingjin, Jin Mei, et al.
Objective: To evaluate the effect and results of transcatheter closure of secundum atrial septal defect (ASD) using CardioSEAL and Amplatzer occluder.
Methods: Twenty patients of mean age 30.00±14.35 (ranged from 9～49) years and weight 57.91±12.23 (ranged from 42～78) kg were evaluated. Guided by fluoroscopy and transesophageal echocardiography, ASD was occluded using CardioSEAL or Amplatzer device through percutaneous procedure. The transthoracic echocardiography ECG and chest film were performed 24 hours, 3 months, 6 months and 1 year after the procedure to evaluate its therapeutic effect and complications.
, 百拇医药
Results: The success rate was 100%, the QP∶QS was 1.09±0.08 (1.00～1.25). The CardioSEAL devices were performed for 6 cases, a very little residual shunt was found in each of 3 cases 24 hours after the procedure, but it was disappeared 1 year later. Two CardioSEAL devices of 23 and 28 mm were used in one patient with two holes. One arm ruptured at 6 months′ follow-up in 1 case without any apparent influence, but still in follow-up. The defect were completely and instantly occluded after the procedure using Amplatzer occluder in 14 cases, one of them was found 3 holes and closed with an Amplatzer occluder of 30 mm. No residual shunt or devices displacement or recanalization was found in follow-up.
Conclusion: Transcatheter closure of ASD is a simple and convenient method of high success rate and reliable curative effect, but the indication of Amplatzer method is much wider and the instant success rate after the procedure is much higher, the remote effect of both methods needs further observation., 百拇医药