清热利湿益气活血法降血尿酸及对肾损害的保护作用

http://www.100md.com 2005年2月1日中国中西医结合急救杂志2005年1月第12卷第1期

     熊湘明1，曲竹秋2，贾锡链2，李沛霖2

    (1.天津公安医院，天津 300050； 2.天津医科大学总医院，天津 300040)

    【摘要】目的：观察清热利湿、益气活血法对实验性高尿酸血症肾损害大鼠血清尿酸水平、肾功能及肾损害的修复作用。方法：采用腺嘌呤联合乙胺丁醇建立动物模型，设立中药复方组、模型组、西药组与正常对照组，检测实验前及实验后第7、14和21 d的血清尿酸、尿素氮(BUN)、肌酐(SCr)水平，行肾组织超微病理学观察。结果：清热利湿、益气活血中药具有降低血清尿酸的作用，其第14 d和21 d血清尿酸水平与模型组比较均明显降低(P均<0.05)；能改善高尿酸血症肾损害大鼠的肾功能，其SCr、BUN已接近正常水平(P均>0.05)；对高尿酸血症肾脏病理损害有修复作用，电镜结果示中药组大鼠肾脏结构基本正常。结论：清热利湿、益气活血法可降低血尿酸，对高尿酸血症肾损害具有预防及治疗作用。

    【关键词】清热利湿益气活血法；高尿酸血症；肾损害；病理组织学变化

    Effect of agents with actions of clearing away heat and dampness(清热利湿) and promoting circulation of Qi and blood(益气活血) protecting renal injury and reducing the level of blood uric acid

    XIONG Xiang-ming1, QU Zhu-qiu2, JIA Xi-lian2, LI Pei-lin. 1. Gongan Hospital,Tianjin 300050, China; 2. The General Hospital of Tianjin Medical University, Tianjin 300040, China

    【Abstract】 Objective： To observe the repairment effect of agents with actions of clearing away heat and dampness(清热利湿) and promoting circulation of Qi and blood (益气活血) on serum uric acid(UA), renal function, as well as protection of kidney injury in rats with hyperuricemia. Methods： Animal model was established by adenine and ethambutol hydrochloride, the rats were then randomly divided into model group, traditional Chinese medicine group, western medicine group, and normal control group. The serum level of UA, blood urea nitrogen (BUN) and serum creatinine (SCr) were measured before the experiment and on the 7 th, 14 th and 21 st day after treatment. The pathologic changes in kidney were observed by electronmicroscope. Results： raditional Chinese medicine of agents with actions of clearing away heat and dampness(清热利湿)and promoting circulation of Qi and blood(益气活血) could lower the level of serum UA, and the UA level was lowered significantly than that in the model group at the 14 th and 21 st day (both P<0.05). It could improve the renal function of experimental rats, and the levels of SCr and BUN were nearly to the normal level (both P>0.05). It could also repair the pathological impairment of kidney, further more, under electronmicroscope, no abnormality was found in kidney. Conclusion： The therapy for clearing away heat and dampness and promating circulation of Qi and the blood can prevent and cure the renal injury in experimental hyperuricemic rats by lowing UA. ......

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