清氮灌肠液治疗慢性肾功能衰竭的临床研究(期刊论文)

清氮灌肠液治疗慢性肾功能衰竭的临床研究

http://www.100md.com 2005年2月1日中国中西医结合急救杂志2005年1月第12卷第1期

     郭兆安¹，武文斌²，姜锡斌¹，焦安钦¹

    (1.山东中医药大学附属医院，山东济南 250011； 2.山东省潍坊市益都中心医院，山东潍坊 262500)

    【摘要】目的：观察清氮灌肠液治疗慢性肾功能衰竭(CRF)的临床疗效并探讨其作用机制。方法：194例CRF住院患者以2∶1的比例随机分为治疗组和对照组，治疗组128例用清氮灌肠液治疗，对照组66例用包醛氧化淀粉治疗；除观察两组治疗前后症状、体征和肾功能相关指标外，还观察了中分子物质(MMS)、甲状旁腺激素(PTH)、血钙(SCa)、血磷(SP)等变化。结果：治疗组经清氮灌肠液治疗后，患者症状、体征积分明显下降(P<0.05)，对照组下降不明显(P>0.05)；治疗组用药后MMS、PTH、SCa、SP均较治疗前改善(P<0.05或P<0.01)，而对照组无明显改善(P>0.05)。治疗组显效74例，有效38例，无效16例，总有效率87.5%；对照组显效18例，有效26例，无效22例，总有效率66.7%；两组疗效比较差异有显著性(χ2=11.72， P<0.01)。结论：清氮灌肠液治疗CRF有较好的疗效，其机制可能与降低MMS和PTH以及改善钙、磷代谢障碍有关。

    【关键词】肾功能衰竭，慢性；中医药治疗；灌肠；中分子物质；甲状旁腺激素

    Clinical study on the Qingdan Guanchang liquid(清氮灌肠液) in treatment of chronic renal failure

    GUO Zhao-an1, WU Wen-bin2, JIANG Xi-bin1, JIAO An-qin1. 1. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong, China; 2. Yidu Central Hospital, Weifang 262500, Shandong, China

    【Abstract】 Objective： To observe the clinical efficacy of Qingdan Guanchang liquid (清氮灌肠液) for treatment of chronic renal failure (CRF) and explore its potential mechanism. Methods：One hundred and ninety-four patients with CRF were divided randomly into two groups with the ratio of 2∶1, the therapeutic group and the control group. Patients in the therapeutic group (128 cases) were administered with Qingdan Guanchang liquid, while those in the control group (66 cases) treated with coated aldehyde oxystarch. Besides the observations on the changes of the clinical symptoms, signs and renal function before and after the treatment, middle molecular substance(MMS), parathyroid hormone (PTH), serum calcium(SCa) and serum phosphorus(SP) were measured in the two groups. Results： Accumulated score of clinical symptoms and signs were decreased after treatment with Qingdan Guanchang liquid (P<0.05), but no significant changes were seen in the control group (P>0.05); MMS, PTH, SCa and SP were improved after treatment in the therapeutic group (P<0.05 or P<0.01), but no changes were found in the control group (P>0.05). In the therapeutic group, 74 cases were remarkably improved, 38 cases were effectives, and 16 cases had no effect, the total effective rate being 87.5%, and they were 18 cases, 26 cases, and 22 cases, 66.7% respectively in the control group. The difference of the clinical efficacy was significantly between the two groups (χ2=11.72, P<0.01). Conclusion： Qingdan Guanchang liquid has a good therapeutic effect for the treatment of CRF. The potential mechanism may be related to the decrease of MMS, PTH and the improvement of metabolic disorder of calcium and phosphorus. ......

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