钙拮抗剂治疗肝纤维化的亚细胞学研究(研究论文)

钙拮抗剂治疗肝纤维化的亚细胞学研究

http://www.100md.com 1996年1月15日《世界华人消化杂志》 1996年第1期

*卫生部青年基金资助课题No.92235,项目负责人,Thesubcellularstudyofcalciumantagonistsintreatmentofhepatofibrosis,Abstract,AIMS,METHODS,RESULTS,CONCLUSIONS,Keywords,摘要,目的,关键词,1材料和方法,2结果,表,2,3,3讨论,4参考文献

     *卫生部青年基金资助课题No.92235

    ¹北京医科大学人民医院肝病研究所北京市 100044

    ²上海第二医科大学新华医院消化研究室 200092

    项目负责人 刘玉兰北京医科大学人民医院肝病研究所北京市 100044

    收稿日期 1995-05-15

    The subcellular study of calcium antagonists in treatment of hepatofibrosis

    Yu-Lan Liu¹,Ding-Guo Li²,Han-Ming Lu ², Zu-Ming Jiang² and Qin-Fang Xu ²

    ¹Institute of hepatology, People's Hospital of Beijing Medical university, Beijing 100044 China

    ²Gastroenterology Research Unit, Xinhua Hospital of Shanghai Second Medical University, Shanghai 200092 China

    Abstract

    AIMS The effects of calcium antagonists (Ca-A) on hepatofibrosis of rats were studied in subcellular level.

    METHODS Hepatofibrosis model was induced in Wistar rats with 40% CCl₄ 0.5 ml/per rat SC, once every three days for 15 times. Then different doses of tetrandrine, verapamil, nifedipine and cinnarizine were used to treat these rats in the early and late hepatofibrotic stages. Mitochondria and inner membrane were separated, MAO and N-acety β - glucosaminidase(NAG) activities were assayed, and mitochondrial inner memeberane superfical and paracentral fuidities were detected. ......

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