肝肿瘤_治疗免疫疗法甲胎蛋白类抗体，单克隆

131I抗AFP抗体-MMC双弹头导向治疗肝癌31例

http://www.100md.com 1997年7月15日《世界华人消化杂志》 1997年第7期

肝肿瘤,治疗免疫疗法甲胎蛋白类抗体，单克隆,项目负责人,Double,bulletradioimmunotargetingtherapyin31patientswithprimarylivercancer,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘,要,目的,方法,结果,结论,主题词

     ¹广西医科大学附属肿瘤医院化疗科广西南宁市 530021

    ²广西肿瘤防治研究所

    国家八五科技攻关基金资助(No.85-914-02-05).

    吴英德，男，1936-02-10生，广西扶绥县人，壮族.1962年广西医科大学医疗系毕业，肿瘤内科主任医师，教授.免疫研究室主任，广西抗癌协会秘书长. 主要从事肝癌导向治疗研究，介入放射学治疗肝癌，肿瘤化疗等，发表论文31篇.

    项目负责人 吴英德,广西南宁市滨湖路6号.

    Tel: 0771-5313022-3137(宅)，3051(办). 收搞日期 1996-07-02 接受日期 1996-12-11

    Double bullet radioimmunotargeting therapy in 31 patients with primary liver cancer

    Ying-De Wu¹, De-Nan Zhou², You-Quan Gang², Xiao-Hua Hu¹, Zhi-Ge Li¹, Xiang-Qun Song¹, Hai-Ping He², Ke-Zheng Yang¹ and Bing-Yan Huang¹¹Department of Chemotherapy, Affiliated Cancer Hospital, Guangxi Medical University, Nanning 530021, China

    ²Guangxi Cancer Intitute, Nanning, Guangxi, China

    Abstract

    AIM To observe the effect of a double bullet immunotargeting therapy with the merit of chemotherapy and internal radiotherapy for primary liver cancer.

    METHODS The polyclonal horse antibody against human AFP (anti-AFPAb) and the monoclonal murine antibody against human AFP (antiAFPMcAb) were used as carriers, and 131I and mitomycin C (MMC) as warheads, to form double bullet, ie, ¹³¹I-anti-AFPMcAbMMC (double bullet 1) and ¹³¹I-anti-AFPAb-MMC (double bullet 2) prepared by the modified chloramine T method. The double bullet targeting therapy was administered by intravenous drip once a month in 31 patients (treatment group) with unresectable primary liver cancer. Among them 4, 17 and 10 patients were administered 1, 2 and 3 times, and the median value of radiation dose (MBq/case) were 193.5±37.74; 651.9±232.4, and 992.0±230.5 respectively. ......

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