中药治疗大鼠胃缺血再灌粘膜损伤
胃疾病,中医药疗法;胃粘膜;再灌注损伤;超氧化物歧化酶,项目负责人,TheeffectCangzhikelijiongastricmucosalinjuryinducedbyischemia-reperfusion,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘,要,目的,方法,结果,结论,主题词
北京市中医研究所药理室 北京市 100010赵子厚，男，1939-09-01生，天津市人，汉族. 1960年北京医学院药学系毕业，药理学研究员，药理室主任，硕士生导师，北京中西结合会理事，本刊编委，发表论文50篇，获各级科技成果奖30项.
项目负责人 赵子厚,北京市东城区美术馆后街23号.
Tel: 010-64016677-2919.收搞日期 1996-07-12 接受日期 1996-12-15
The effect Cangzhikeliji on gastric mucosal injury induced by ischemia-reperfusion
Zi-Hou Zhao, Li-Hong Ma, Suo-Ya Zhang, Dai-Ying Liang, Xiao-Li Ma and Chun-Miao Li
Department of Pharmacology, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
Abstract
AIM To study the relationship between the gastric mucosal injury reduced by ischemia-reperfusion (IR) and OFR, and the protective effect Cangzhikeliji (a formula composed of 11 kinds of traditional Chinese herbal medicine) on gastric mucosa.
METHODS The gastric mucosal injury was produced in rats by applying a small clamp to the celiac artery for 30 min and by removal of the clamp for 60 min. Then the rats were killed, gastric mucosa removed and SOD, LPO, CAT, GSH-PX, PGE2 and NPSH were detected.
RESULTS LPO levels of gastric mucosa in IR rats were significantly higher, SOD (82.7NU/mg±17.0NU/mg), NPSH (0.22mmol/mg±0.05mmol /mg) and GSH-PX (18.7U/mg±2.2U/mg) levels were lower than that in control group (P<0.01). LPO levels of gastric mucosa in the rats given Cangzhikeliji before operation were much lower, SOD (146.5NU/mg±47.4NU/mg), NPSH (0.43mmol/mg±0.08mmol/mg) and GSH-PX (24.2U/mg±5.7U/mg) levels were significantly higher than that in IR rats (P<0.05, P<0.01). And there were no significant differences in PGE2 and CAT levels of gastric mucosal among various groups. ......
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