肝肿瘤_代谢;癌，肝细胞_代谢;载体蛋白质类

原发性肝癌组织P16蛋白的缺失与HBV感染

http://www.100md.com 1997年11月15日《世界华人消化杂志》 1997年第11期

肝肿瘤,代谢;癌，肝细胞,代谢;载体蛋白质类,代谢;肝炎，乙型,并发症,作者简介,DeletionofP16proteininprimarylivercarcinomaanditscorrelationwithHBVinfection,Subjectheadings,Abstract,AIM,METHODS,RESULTS,CONCLUSION,主题词

     江西医学院病理学教研室江西省南昌市 330006

    作者简介 吴绮明，女，1963-05-05生，江西省南昌市人，汉族. 1986年江西医学院医学系本科毕业，主管技师，发表论文6篇

    [江西省南昌市八一大道461号. 电话(0791)8627217-2317].(收稿 1997-05-23 修回 1997-07-21)

    Deletion of P16 protein in primary liver carcinoma and its correlation with HBV infection

    WU Qi-Ming and ZHUANG Wen-Hua

    Department of Pathology, Jiangxi Medical College, Nanchang 330006, Jiangxi Province, China

    Subject headings liver neoplasms/metabolism; carcinoma, hepatocellular/metabolism; carrier proteins/metablism; hepatitis B/complications

    Abstract

    AIM To study the relationship between the deletion of P16 protein and the occurrence and development of primary carcinoma, and HBV infection.

    METHODS The P16 protein and HBsAg in primary liver carcinoma were detected by immunohistochemical technic in 70 cases of primary liver cancer.

    RESULTS P16 protein was undetactable in 60.6%(40/66) of hepatocellular carcinoma (HCC) and 75.0%(3/4) of cholangiocellular carcinoma (CCC). P16 protein deletion rates in HCC of grades Ⅰ,Ⅱ,Ⅲ and Ⅳ were 0.0%(0/1), 44.1%(15/34) ......

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