Expression and prognostic significance of P53 protein during colorectal tumorigenesis
ExpressionandprognosticsignificanceofP53proteinduringcolorectaltumorigenesis,Correspondenceto,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,INTRODUCTION,,MATERIALSANDMETHODS,Tissuesamples,Immunohistochemistry,Controls,Statistics,RESULTS,E
1Department of Gastroenterology, General Hospital of Chinese PLA Guangzhou Command Area, Guangzhou 510010, China2Department of Gastroenterology, Guangzhou Sun Yat-Sen Memorial Hospital, Guangzhou 510120, China
Dr. Xiao-Qiang Zhuang, male, born on 1963-06-03 in Guangzhou, physician-in-charge, master of gastroenterology,having 30 papers published.
Correspondence to Xiao-Qiang Zhuang, Department of Gastroenterology,General Hospital of Chinese PLA Guangzhou Command Area, Guangzhou 510010, China
Tel. +86·20·86664097
Received 1997-11-20
Abstract
AIM To study expression and prognostic significance of P53 protein in colorectal tumors.
METHODS We detected the p53 expression in 45 cases of colorectal adenomas and 61 cases of colorectal carcinomas by immunohistochemical staining.
RESULTS The p53 positive rate was significantly higher in adenoma and carcinoma than the normals (P<0.01). In colorectal adenoma, p53 expression increased with the increase of size and dysplasia, which was higher in adenomas ≥20mm than that <10mm (77.78% vs 35.00% ......
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