亚硒酸钠对胃粘膜细胞非程序DNA合成、LPO和ras P21表达的影响
亚硒酸钠,药理学;胃粘膜,药物作用;DNA,生物合成;过氧化脂质类,代谢;癌基因蛋白质P21(RAS),代谢,亚硒酸钠对胃粘膜细胞非程序DNA合成、LPO和rasP21表达的影响,项目负责人,Correspondenceto,EffectsofNa,2SeO3onunscheduledDNAsynthesis,lipidperoxidationandrasP21expressionin
第三军医大学西南医院消化科 重庆市 400038房殿春，男，1951-06-22生，吉林省长春市人，汉族. 1979年第三军医大学军医系毕业，现为第三军医大学第一附属医院消化内科教授，主任医师，博士生导师，中华消化内镜学会常委，全军消化内科专业委员会副主任委员，主要从事胃癌早期诊治研究，发表论文160篇，参加编写专著4部，获国家和军队科技进步奖10项.
项目负责人 房殿春，400038，第三军医大学西南医院消化科，重庆市沙坪坝区高滩岩正街30号.
Correspondence to Dian-Chun Fang, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Zhengjie, Shapingba District, Chongqing 400038, China
Tel. +86·23·68754625， Fax. +86·23·65316682
收稿日期 1998-01-30
Effects of Na2SeO3 on unscheduled DNA synthesis, lipid peroxidation and ras P21 expression in gastric epithelial cells
Dian-Chun Fang, Wei Liu, Hou-Jie Liang and Wei-Wen Liu
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Abstract
AIM To evaluate the preventive effects of Na2SeO3 on gastric epithelial cells (GEC) damaged by N-methyl-N＇-nitrosoguanidine (MNNG).
METHODS Effects of Na2SeO3 on unscheduled DNA synthesis (UDS), lipid peroxidation and ras P21 expression in GEC induced by MNNG were observed. ......
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