肝硬变患者前列腺素E1治疗后血清HA，PⅢP，CⅣ的变化
肝硬化,药物疗法;前列地尔,治疗应用;透明质酸,血液;胶原,血液,项目负责人,Correspondenceto,AlterationsofserumHA,P,ⅢPandCⅣinpatientswithlivercirrhosistreatedwithPGE1,Abstract,,AIM,METHODS,RESULTS,CONCLUSION
贵阳医学院附属医院消化内科 贵州省贵阳市 550004张永宏，男，1956-12-18生，贵州省沿河县人，土家族. 1982年贵阳医学院本科毕业，1997年贵阳医学院消化科硕士研究生毕业，讲师，主治医生，主要从事消化内科专业研究工作，发表论文3篇.
项目负责人 张永宏，550004，贵阳医学院附属医院消化内科，贵州省贵阳市北京路4号.
Correspondence to Yong-Hong Zhang, Department of Gastroenterology, Affiliated Hospital of Guiyang Medical College, 4 Beijinglu, Guiyang 550004, Guizhou Province, China
Tel. +86·851·6821126
收稿日期 1997-01-20
Alterations of serum HA, PⅢP and CⅣ in patients with liver cirrhosis treated with PGE1
Yong-Hong Zhang, Li Zhou, Yuan Lu and Tao Zhang
Department of Gastroenterology, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China
Abstract
AIM To study the clinical significance of alterations of serum hyaluronic acid, type Ⅲ procollagen and type Ⅳ collagen in patients with liver cirrhosis pre or post PGE1 treatment.
METHODS Serum hyaluronic acid (HA), procollagen Ⅲ peptide (PⅢP) and collagen Ⅳ (CⅣ) were measured with radioimmunoassay in 70 patients with liver cirrhosis and 30 normal persons. The patients with hepatic cirrhosis were randomly divided into two groups. The control group (n=30) were given comprehensive treatment for 4 weeks and the experimental group (n=40) received extra prostagland E1 (PGE1). The concentration of HA, PⅢP, CⅣ in child class A was less than that of class B, which was less than that of class C, before the treatment (A
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