亮啡肽与大鼠胃电节律失常的关系
脑啡肽，亮氨酸,分析;胃,神经支配;胆碱能纤维;乙酰胆碱,代谢;胃,病理生理学,项目负责人,Correspondenceto,Relationshipbetweenelectrogastricdysrhythmiaandleucin-enkephalininrats,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjecthead
1第三军医大学西南医院消化科 重庆市 4000382现成都军区总医院消化科 四川省成都市 610083
张勇，男，1967-12-17生，重庆市壁山人，汉族. 1990年第三军医大学军医系本科毕业，1995年获医学硕士学位.
现任成都军区总医院消化科主治医生.
项目负责人 张勇，610083，四川省成都市成都军区总医院消化科.
Correspondence to Yong Zhang, Department of Gastroenterology, General Hospital, Chinese PLA Chengdu Command Area, Chengdu 610083, Sichuan Province, China
Tel. +86·28·6570549(H)
收稿日期 1998-03-08
Relationship between electrogastric dysrhythmia and leucin-enkephalin in rats
Yong Zhang1,2, Zhen-Hua Wang1 and Mao-Tao Huang1
1Department of Gastroenterology, Southwest Hospital, Third Military Medical College, Chongqing 400038, China
2Department of Gastroenterology, General Hospital, Chinese PLA Chengdu Command Area, Chengdu 610083,Sichuan Province, China
Abstract
AIM To study the relationship between electrogastric dysrhythmias and leucin-enkephalin.
METHODS Wistar rats were randomly divided into 3 groups: control (n=20), model group (n=30) and drug group (n=10). In model group, rats were fed irregularly for 4 weeks (fasted for 24h every other day). Then the silver electrodes were implanted on antrum. Seven days later, gastric electric slow wave and fast wave were recorded. The effects of morphine and naloxone on gastric myoelectric activity were investigated in drug group. In control and model groups, the contents of leucin-enkephalin (L-enk) in plasma and the tissue of antrum were measured; the L-enk immunoreactive nerves and cholinergic (Ach) nerves in antral myenteric plexus were demonstrated by immunocytochemistry and histochemistry, and measured by image analysis systems. ......
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