血管内皮生长因子;免疫学;抗体治疗应用;腹腔粘连;血管通透性

应用VEGF抗体预防术后腹腔粘连的实验研究

http://www.100md.com 1999年3月15日《世界华人消化杂志》 1999年第3期

血管内皮生长因子;免疫学;抗体治疗应用;腹腔粘连;血管通透性;疾病模型,动物,项目负责人,Correspondenceto,Preventionofpostoperative,abdominaladhesionsbyanantibodytoVEGFinmice,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subj

     第一军医大学附属珠江医院 ¹普通外科 ²内分泌科广东省广州市 510282

    郑振华，男，1968-07-28生，山东省日照市人，汉族. 1993年第二军医大学军医系毕业，现为第一军医大学普通外科研究生，主要从事周围肢体缺血性疾病的诊治研究，发表论文2篇.

    项目负责人 郑振华，510282，第一军医大学附属珠江医院普通外科，广东省广州市工业大道253号.

    Correspondence to Zhen-Hua Zheng, Department of General Surgery, Zhujiang Hospital, 253 Gongye Dadao, Guangzhou 510282, Guangdong Province, China

    Tel. +86·20·84339888 Ext. 88369

    收稿日期 1998-08-05

    Prevention of postoperative abdominal adhesions by an antibody to VEGF in mice

    Zhen-Hua Zheng¹, Hua Zhang², Yu-Xian Pan¹, Yi Gao¹ and Ji-Zhen Yang¹

    ¹Department of general Surgery, ²Department of Endocrinology, Zhujiang Hospital, First Military Medical University,Guangzhou 510282, Guangdong Province, China

    Abstract

    AIM To assess the ability of vascular endothelial growth factor (VEGF) antibody to prevent postoperative abdominal adhesion formation in mice.

    METHODS Twenty-four Kunming mice were randomly divided into two groups: anti-VEGF group (n=12) and control group (n=12). After an identical peritoneal injury operation, mice were treated intraperitoneally with either VEGF antibody or 154mmol/L sodium chloride at the time of abdominal closure. The mice were killed on postoperative day 20, the abdominal incisions and the development of intraabdominal adhesions was determined. Adhesion scoring was based on an overall assessment of the extent, location, and type of adhesions present. ......

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