结直肠切除术后早期肠内营养的前瞻性研究
结直肠切除术;肠内营养;前瞻性研究,项目负责人,Correspondenceto,Earlyenteralnutritionaftercolorectalresections:aprospectiveclinicaltrial,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方法,结果
南京医科大学第一附属医院胃肠外科 江苏省南京市 210029吴文溪，1947-01-24生，江苏省无锡市人，汉族. 1970年上海第一医学院医学系毕业，学士，1981年上海第一医学院硕士，教授，外科总论教研室副主任，从事胃肠外科疾病诊治研究，发表论文50篇，主编《临床重症监护与治疗》等3部著作.
项目负责人 吴文溪，210029，江苏省南京市广州路300号，南京医科大学第一附属医院胃肠外科.
Correspondence to Dr. Wen-Xi Wu, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road,Nanjing 210029, Jiangsu Province, China
Tel. +86·25·6619960
Email. wuwenxi@public 1,ptt.js.cn
收稿日期 1999-09-15 接收日期 1999-11-08
Early enteral nutrition after colorectal resections: a prospective clinical trial
Wen-Xi Wu, Qin Xu, Yi-Bing Hua and Li-Zhong Shen
Department of Gastroenterologic Surgery, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029, Jiangsu Province, China
Abstract
AIM To evaluate the feasibility of early postoperative enteral nutrition (EN) in colorectal surgery and compare the metabolic effects and histologic changes of colonic mucosa following EN or total parenteral nutrition (TPN).
METHODS Patients undergone open elective colorectal resections were randomized to either early EN or control (TPN) group. Fifteen patients in EN group had a nasal-jejunal tube inserted during the operation. The enteral feeding with a formula containing fiber started within the first 24 hours postoperatively and continued for consecutive 7 days. The full load of EN provided 0.18ng/(kg·d) and 104.5kJ/(kg·d) of non-protein energy. Fifteen patients in control group received total parenteral nutrition via peripheral vein postoperatively and provided 0.10ng/(kg·d) and 101kJ/(kg·d) of non-protein energy for 7 days. Anthropometric, biochemical parameters and visceral functions were monitored. Colonoscopic examination with mucosa biopsy were taken in 6 patients of EN group and 4 patients of parenteral nutrition (PN) group preoperatively and followed up for 8 days postoperatively. The microstructure of the colonic mucosa was studied. ......
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