小剂量心得安加川芎嗪预防食管静脉曲张破裂出血的实验与临床研究
心得安,治疗应用;川芎嗪,治疗应用;肝硬化;血流动力学;高血压,门静脉;食管静脉曲张,药物疗法,项目负责人,Correspondenceto,Lowdosepropranololincombinationwithligustrazineforpreventionofrecurrentesophagealva
重庆医科大学第二医院消化科 重庆市 400010李孝生，男，1952-10-01生，重庆市人，汉族. 1977年重庆医科大学医疗系毕业，1990年大连医科大学消化专业硕士，现为重庆医科大学第二医院消化科副主任医师，副教授，消化专业硕士生导师. 主要从事肝硬变及门脉高压症的诊治研究，已发表论文26篇.
项目负责人 李孝生，400010，重庆市，重庆医科大学第二医院消化科.
Correspondence to Xiao-Sheng Li, Department of Gastroenterology, Second Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China
收稿日期 1999-09-22 接收日期 1999-12-02
Low dose propranolol in combination with ligustrazine for prevention of recurrent esophageal varices bleeding: a randomly controlled experimental and clinical study
Xiao-Sheng Li, Ding-Ming Shen, Jian-Zhong Zou, Chang-An Liu and Lian Zhang
Department of Gastroenterology, Second Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China
Abstract
AIM To assess the efficacy of low dose propranolol in combination with ligustrazine for the prevention of reurrent esophageal varices bleeding in liver cirrhosis, and its mechanism.
METHODS By detecting portal pressure of experimental liver cirrhotic dogs (n=8) directly and measuring portal system flow in patients with portal hypertension and esophageal varices by color Doppler flow imaging, the therapeutic efficacy and safety of the therapy were investigated. Two comparable groups of 38 and 36 cases were used (taking propranolol 10mg plus ligustrazine 50mg or vitamin B1 10mg plus vitamin pp50mg three times a day, respectively). ......
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