卵泡抑素对肝纤维化大鼠细胞增殖及激活素A的影响
抑制素;增殖细胞核抗原;溴脱氧尿苷;转化生长因子;肝硬化;免疫组织化学;肝星状细胞,项目负责人,Correspondenceto,FollistatinonhepaticfibroticratliverPCNA,BrDUandactivinAexpression,,Abstract,AIM,METHODS,-1,RE
上海第二医科大学附属新华医院消化内科 上海市 200092黄新，男，1972-07-17，河南省郑州市人，汉族. 1990至1998年在河南医科大学攻读学士、硕士学位998至今在上海第二医科大学附属新华医院攻读消化内科博士学位，发表论文6篇.
项目负责人 黄新，200092，上海市控江路1665号，上海第二医科大学附属新华医院消化科.
Shanghai Second Medical University Affiliated Xinhua Hospital, Shanghai 200092, China
Correspondence to Dr. Xin Huang, Department of Digestive Diseases, Xinhua Hospital, 1665 KongJiang Road,Shanghai 200092, China
Tel. 0086-21-65790000 Ext.5319
收稿日期 2000-05-12 接收日期 2000-05-16
Follistatin on hepatic fibrotic rat liver PCNA, BrDU and activin A expression
Xin Huang, Ding-Guo Li, Zhi-Rong Wang, Hong-Shan Wei, Ji-Lin Cheng, Yu-Tao Zhan, Qin-Fang Xu and Han-Ming Lu
Abstract
AIM To study the effect of gene recombinant human follistatin on the proliferating activity and activin A expression in the liver of rat experimental hepatic fibrosis model.
METHODS Liver fibrosis was induced in rats by subcutaneous injection of 400mL·L-1 carbon tetrachloride oily solution for a period of 7 weeks. The 16 hepatic fibrosis rats were randomly divided into treatment group (n=8) and sham operation group (n=8). Another 8 normal rats were taken as normal control group. rh-FS (1μg) was infused into the portal vein via ileocolic vein. After 24 hours, the rats were killed. PCNA, nuclear bromodeoxyuridine labeling and activin β A expression were measured. ......
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