严重创伤后肠屏障功能损伤及谷氨酰胺的保护
肠,损伤;应激障碍，创伤后;二胺氧化酶;谷氨酰胺;肿瘤坏死因子;大鼠,基金资助项目：全军“九五”指令性课题(,96L053),项目负责人,SupportedbytheDesignatedProjectofthe,“NinthFive-YearPlan”ofChinesePLA(96L053),Correspon
中国人民解放军304医院烧伤研究所 北京市 100037黎君友，男，1950生，汉族，广东省云浮市人，副研究员. 从事创伤生化和代谢研究，发表论文50篇.
基金资助项目：全军“九五”指令性课题(96L053)
项目负责人 黎君友，100037，北京市阜成路51号，中国人民解放军304医院烧伤研究所.
Burn Institute, Chinese PLA 304 Hospital, Beijing 100037, China
Supported by the Designated Project of the “Ninth Five-Year Plan” of Chinese PLA (96L053)
Correspondence to Jun-You Li, Burn Institute, Chinese PLA 304 Hospital, 51 Fuchenglu Beijing 100037, China
Tel. 0086-10-66867395, Fax 0086-10-68429998
Email. WuZG@A-1.net.cn
Received 2000-05-12 Accepted 2000-05-16
Severe trauma induced intestinal barrier function injury and protection
Jun-You Li, Zhi-Yong Sheng, Yi Lu, Yong Yu, Sen Hu and Bao-Tong Zhou
Abstract
AIM To investigate the mechanism of intestinal barrier function injury after severe trauma and protection by glutamine.
METHODS Burned patients and animal models of severe trauma replicated by hemorrhagic shock combined with endotoxin infusion and burn injury were observed. Effects of oral glutamine on intestinal barrier function were observed in scalded rats. Various parameters were studied in these experiments as follows: ① Plasma levels of diamine oxidase (DAO),tumor necrosis factor (TNF), lipopolysaccharide (LPS) and lactate and D-lactate by biochemical methods; ② lactulose/mannitol (L/M) rate in urine by SP-3400; ③ pathological examination of intestinal mucosa by LM. ......
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