选择性内皮素受体拮抗剂对肝硬变门脉高压症大鼠血流动力学的影响
肝硬化;高血压，门静脉;内皮素;高动力循环;选择性内皮素受体拮抗剂;血流动力学;大鼠,项目负责人,Correspondenceto,Hemodynamicinfluenceofselectiveendothelinreceptorantagonistsonportalhypertensiverat
上海医科大学中山医院消化科 上海市 200032张弛，男，1972-02-13生，江苏省江阴市人，临床医学专业学士，主要从事胃肠疾病和肝病的临床诊治工作.
项目负责人 王吉耀，200032，上海市枫林路180号，上海医科大学中山医院消化科.
Department of Gastroenterology, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China
Correspondence to Prof. Ji-Yao Wang, Department of Gastroenterology, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China
Tel. 0086-21-64041990 Ext.2420
Email. xhk@shmu.edu.cn
Received 2000-09-18 Accepted 2000-10-08
Hemodynamic influence of selective endothelin receptor antagonists on portal hypertensive rats
Chi Zhang, Jian-Jun Liu and Ji-Yao Wang
Abstract
AIM To investigate the hemodynamic influence of selective endothelin receptor (ETR) antagonists on portal hypertensive (PHT) rats.
METHODS PHT rats were induced by CCl4 and received saline (control), BQ123 (the endothelin receptor A antagonist, 5 or 10nmol·kg-1·min-1), BQ788 (the endothelin receptor B antagonist, 10nmol·kg-1·min-1), BQ123 + BQ788 (both 10nmol·kg-1·min-1) respectively for 1h. During the administration, heart rate (HR),arterial pressure (MAP) and portal pressure (PP) were monitored, and the hemodynamic study was performed using the radioactive microsphere method after 1 hour administration. ......
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