胃癌多药耐药细胞药物积累的异常
胃肿瘤;多药耐药;药物积聚;长春新碱;柔红霉素;抗肿瘤药,项目负责人,Correspondenceto,Abnormaldrugaccumulationinmultidrugresistantgastriccarcinomacells,,Abstract,AIM,METHODS,RESULTS,CONCLUSION,Subjectheadings,摘要,目的,方
上海第二医科大学附属瑞金医院消化科 上海市 200025程时丹，女，1969-07-25生，上海市人，汉族. 1993年上海第二医科大学临床医学系毕业，医学硕士.
项目负责人 程时丹，200025，上海第二医科大学附属瑞金医院消化科.
Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Correspondence to Dr. Shi-Dan Cheng, Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University,Shanghai 200025, China
Tel. 0086-21-64370045 Ext. 665241
Received 2000-05-18 Accepted 2000-06-02
Abnormal drug accumulation in multidrug resistant gastric carcinoma cells
Shi-Dan Cheng, Yun-Lin Wu, Yong-Ping Zhang, Min-Min Qiao and Qiang-Su Guo
Abstract
AIM To study the difference in intracellular concentration of drug between multidrug resistant cells and drug sensitive cells
of gastric carcinoma.
METHODS Multidrug resistant gastric carcinoma cell sublines were established by a stepwise increase of concentration of vincristine in media. The uptake of drug was measured by isotope liquid scintillation counter. Laser confocus microscope was used to study the intracellular distribution of daunorubicin and fluorescent intensity of daunorubicin in drug- resistant and drug-sensitive cells after incubated in drug-free media for various time periods. ......
您现在查看是摘要页，全文长 21635 字符。