大鼠肝纤维化形成中肝窦壁层粘连蛋白及Ⅳ型胶原蛋白的变化
肝硬化;蛋白质类;胶原;肝窦毛细血管化;免疫组织化学;大鼠,1998,年国家杰出青年科学基金，No.39825128；上海市教委曙光计划资助课题，No.99SG44,项目负责人,SupportedbyShuguangProgramProjectofShanghaiEducation
上海中医药大学肝病研究所 上海市 200032陆雄，男，1965-11-26生，上海市人，汉族. 上海中医药大学中西医结合硕士，讲师，博士研究生，主要从事消化系统疾病的病理学研究，发表论文7篇.
1998年国家杰出青年科学基金，No. 39825128；上海市教委曙光计划资助课题，No. 99SG44
项目负责人 刘平，刘成海，200032，上海市零陵路530号，上海中医药大学肝病研究所.
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Supported by Shuguang Program Project of Shanghai Educational Committee, No. 99SG44
Correspondence to Xiong Lu, Institute of Liver Disease, Shanghai University of Traditional Chinese Medicine, 530 Lingling Road,Shanghai 200032, China
Tel. 0086-21-54232067
Email. xionglu65@yahoo.com
Received 2000-09-19 Accepted 2000-09-28
Successive observation of laminin and collagen Ⅳ on hepatic sinusoid during the formation of the liver fibrosis in rats
Xiong Lu, Cheng-Hai Liu, Guang-Fu Xu, Wen-Hui Chen and Ping Liu
Abstract
AIM To investigate the variations of LN and Col Ⅳ in perisinusoids during the formation of liver fibrosis in rats.
METHODS Liver fibrosis was induced in rats after administration of dimethylnitrosamine (DMN) intraperitoneally three times a week for 4 weeks. The animals were killed on day 2 and weeks 1, 2, 3, 4, 5, 6, 8, 12 and 24. Immunohistochemistry for LN and Col Ⅳ was used to outline the formation of basement membrane on hepatic sinusoids. ......
您现在查看是摘要页，全文长 14515 字符。