乙醇对清醒兔Oddi括约肌运动功能的影响
奥狄氏括约肌运动,药物作用;乙醇,药理学;测压法,方法;括约肌切开术,经肝;胰腺炎,病因学,项目负责人,Correspondenceto:,EffectofethanolonsphincterofOddimotilityinconsciousrabbits,Abstract,AIM,METHODS,RESULTS,CONCLUSI
中国人民解放军空军总医院消化科 北京市 100036杨春敏, 1965-05-22生, 四川省阆中市人, 汉族. 1987年第三军医大学毕业, 1995年和1998年分别获得中国协和医科大学医学硕士和医学博士学位, 副主任医师,主要从事胃肠动力研究工作, 发表论文20篇.
项目负责人 杨春敏, 100036, 北京市海淀区阜成路30号, 中国人民解放军空军总医院消化科.
Department of Gastroenterology, Genenral Hospital of Air Force, Beijing 100036, China
Correspondence to:Chun-Min Yang, Department of gastroenterology, Genenral Hospital of Air Force, 30 Fuchenglu, Haidian District, Beijing 100036, China
Tel. 0086-10-66928139
Email. cmyang@263.net
Received 2001-01-08 Accepted 2001-01-11
Effect of ethanol on sphincter of Oddi motility in conscious rabbits
Chun-Min Yang, Gao-Ping Mao, Ming Zhu, Xiu-Rong Zhang and Ying-Hui Zhang
Abstract
AIM Alcohol is one of the factors which induces pancreatitis. This study was to observe whether ethanol would affect sphincter of Oddi (SO) motility.
METHODS A manometric catheter for measuring SO pressure and a silastic cannula for drugs were aseptically implanted into the common bile duct and the mid-duodenum respectively in each of 8 rabbits. Experiment began 7 days after recovery from operation. The changes of SO pressure was recorded in both ethanol group and control group, using low compliance capillary water perfusion system. Various doses of ethanol (50mL·L-1, 150mL·L-1 , 300mL·L-1) each were infused intraduodenally (id) or intravenously (iv) within 30 min at a rate of 0.5mL·min-1 in two-three separate days. Normal saline was given instead of ethanol in control group. ......
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