沈阳市第六人民医院传染科 辽宁省沈阳市 110006

    杨晴，女，1962-12-17生，沈阳市人，副主任医师.项目负责人 杨晴，110006，沈阳市第六人民医院传染科

    收稿日期 2001-05-31 接受日期 2001-06-20

    Inhibitory effect of Quxianruangan Capsulae on liver fibrosis in rats a nd chronic hepatitis patients

    Qing Yang, Ying-Chun Yan and Yan-Xin Gao

    Shengyang City Sixth Hospital Post Code 110006

    Correspondence to: Qing Yang Department of Inflectious Diseases Sixth Hospital of Shenyang City

    Received 2001-07-19 Accepted 2001-07-19

    Abstract

    AIM To Study the effect of Quxianruangan Capsulae in anti-he patofibrosis.

    METHODS The heapatofibrosis model was induced by 500mg·kg ^-1 carbontetrachloride(CCL4) oily solution(with olive oil). Fifty rats were r and omly divided into three groups(untreated group:12; model group:19; treatment group 19). The group was treated by Quxianruangan Capsulae. Liver tissue was st udied with histopathlogical assay.The area of collagen was studied using color a nalysis system. Its serum levels of hyaluronic acid(HA),laminin(LN),typeIV colla gen(CIV) and typeⅢ precollagen(PCIII) and others were tested. Eighty-two chro nic hepatitis B and chrrhosis of liver were selected. The patients were randomly divided into two group - treatment group(n=41) and routine group(n=41) . The patients were followed up for 3 months. ......