李军华,于皆平,徐细明,武汉大学人民医院消化内科 湖北省武汉市 430060

    何小飞,咸宁医学院附属医院消化内科 湖北省咸宁市 437100

    李军华,男,1976-07-25生,湖北省天门市人,汉族.武汉大学人民医院消化内科硕士研究生,主要从事胃肠道肿瘤的基础与临床研究.

    项目负责人:李军华,430060,湖北省武汉市,武汉大学人民医院消化内科. lihard@163.com

    电话:02788041911-2135

    收稿日期:2002-08-10 接受日期:2002-09-03

    Expression of NF-kB in rats with TNBS-induced ulcerative colitis

    Jun-Hua Li,Jie-Ping Yu,Xiao-Fei He,Xi-Ming Xu

    Jun-Hua Li, Jie-Ping Yu, Xi-Ming Xu,Department of Gastroenterology,The Renmin Hospital of Wuhan University,Wuhan 430060,HuBei Province,China

    Xiao-Fei He,Department of Gastroenterology,The Affiliated Hospital of Xianning Medical College,Xianning 430071, HuBei Province,China

    Correspondence to: Dr. Jun-Hua Li,Department of Gastroenterology,The Renmin Hospital of Wuhan University,Wuhan 430060,HuBei Province,China. lihard@163.com

    Received:2002-08-10 Accepted:2002-09-03

    AbstractAIM:To investigate the role of NF-kB in the pathogenesis of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.

    METHODS:Ulcerative colitis model in rat was induced by TNBS.The expression of NF-kB, TNF-a and ICAM-1 protein in colon tissues were detected by immunohistochemistry. The myeloperoxidase (MPO) activity in colon mucosa was detected by biochemistry.The pathological changes in the colon were examined,the relationships among the activity of NF-kB, TNF-a, ICAM-1, and MPO were evaluated. ......