乙肝病毒表面抗原基因启动子II的结构及调节研究
梁耀东,成军,陆荫英,中国人民解放军第302医院传染病研究所基因治疗研究中心、全军病毒性肝炎防治研究重点实验室 北京市 100039
吴君,程明亮,贵阳医学院第一附属医院感染科 贵州省贵阳市 550004
项目负责人:成军,100039,北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心、全军病毒性肝炎防治研究重点实验室.cj@genetheray.com.cn
电话:010-66933392 传真:010-63801283
收稿日期:2003-01-11 接受日期:2003-02-16
, http://www.100md.com
梁耀东,成军,陆荫英,吴君,程明亮.乙肝病毒表面抗原基因启动子II的结构及调节研究.世界华人消化杂志 2003;11(7):1004-1006
De Meyer S, Gong ZJ, Suwandhi W, van Pelt J, Soumillion A, Yap SH.Organ and species specificity of hepatitis B
virus (HBV) infection: a review ofliterature with a special reference to preferential attachment of HBV tohuman
hepatocytes. J Viral Hepat 1997;4:145-153
4 Sonveaux N, Thines D, Ruysschaert JM. Characterization of the HBsAg particle lipid membrane. Res Virol
, 百拇医药
1995;146:43-51
5 Mangold CM, Unckell F, Werr M, Streeck RE. Analysis ofintermolecular disulfide bonds and free sulfhydryl groups
in hepatitis B surface antigen particles.Arch Virol 1997;142:2257-2267
6 Xu Z, Bruss V, Yen TS. Formation of intracellular particles byhepatitis B virus large surface protein. J Virol
1997;71:5487-5494
, http://www.100md.com
7 成军,杨守纯. 现代肝炎病毒分子生物学. 第1版.北京: 人民军医出版社, 1997:25-43
8 金奇. 医学分子病毒学. 第1版. 北京:科学出版社, 2001:334-335
9 Alka S, Hemlata D, Vaishali C, Shahid J, Kumar PS, Hepatitis B virus surface(S) transactivator with DNA-binding
properties. J Med Virol 2000;61:1-10
10 De Meyer S, Depla E, Maertens G, Soumillion A, Yap SH. Characterization ofsmall hepatitis B surface antigen
, 百拇医药
epitopes involved in binding to humanannexin V. J Viral Hepat 1999;6: 277285
11 Lu CC, Chen M, Ou JH, Yen TS. Key role of a CCAAT element inregulating hepatitis B virus surface protein
expression. Virology 1995;206:1155-1158
12 季伟,王慧芬.乙型肝炎病毒转录后调节机制的研究进展.国外医学.流行病学传染病学分册2000;27:120-124
13 吴炜,李兰娟. HBV前S基因变异及其临床意义.国外医学.流行病学传染病学分册 2002;29:200-202
, 百拇医药
14 Bock CT, Kubicka S, Manns MP, Trautwein C. Two control elements in the hepatitis B virus S-promoter are important
for full promtoter activity mediated by CCAAT-binding factor. Hepatology 1999;29:1236-1247
15 Bock CT, Tillmann HL, Manns MP, Trautwein C. The pre-S region determines the intracellular localization and
appearance of hepatitis B virus. Hepatology 1999; 30:517-525
, http://www.100md.com
16 Bock CT, Tillmann HL, Maschek HJ, Manns MP, Trautwein C. A preS mutation isolated from a patient with chronic
hepatitis B infection leads to virus retention and misassembly.Gastroenterology 1997;113:1976-1982
17 Ha-Lee YM, Lee J, Pyun H, Kim Y, Sohn J, Cho YJ, Kim Y. Sequencevariations of hepatitis B virus promoter regions
in persistently infected patients. Arch Virol 2001;146:279-292
, http://www.100md.com
18 Kajiya Y, Hamasaki K, Nakata K, Nakagawa Y, Miyazoe S, Takeda Y, Ohkubo K, Ichikawa T, Nakao K, Kato Y, Eguchi
K. Full-length sequence and functionalanalysis of hepatitis B virus genome in a virus carrier:a case reportsuggesting
the impact of pre-S and core promotermutations on the progression of the disease. J Viral Hepat 2002;9:149-156
19 Raney AK, McLachlan A. Characterization of the hepatitis B virusmajor surface antigen promoter hepatocyte nuclear
, http://www.100md.com
factor 3 binding site. J Gen Virol 1997;78:3029-3038
20 Li J, Ou JH. Differential regulation of hepatitis B virus gene expression by the SP1 transcription factor. J Virol
2001;75: 8400-8406
21 Bogomolski-Yahalom V, Klein A, Greenblat I, Haviv Y, Tur-Kaspa R. The TATA-less promoterof hepatitis B virus S
gene contains a TBP binding site and anactive initiator. Virus Res 1997;49:1-7, http://www.100md.com( 梁耀东, 成 军, 陆荫英, 吴 君, 程明亮)
吴君,程明亮,贵阳医学院第一附属医院感染科 贵州省贵阳市 550004
项目负责人:成军,100039,北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心、全军病毒性肝炎防治研究重点实验室.cj@genetheray.com.cn
电话:010-66933392 传真:010-63801283
收稿日期:2003-01-11 接受日期:2003-02-16
, http://www.100md.com
梁耀东,成军,陆荫英,吴君,程明亮.乙肝病毒表面抗原基因启动子II的结构及调节研究.世界华人消化杂志 2003;11(7):1004-1006
De Meyer S, Gong ZJ, Suwandhi W, van Pelt J, Soumillion A, Yap SH.Organ and species specificity of hepatitis B
virus (HBV) infection: a review ofliterature with a special reference to preferential attachment of HBV tohuman
hepatocytes. J Viral Hepat 1997;4:145-153
4 Sonveaux N, Thines D, Ruysschaert JM. Characterization of the HBsAg particle lipid membrane. Res Virol
, 百拇医药
1995;146:43-51
5 Mangold CM, Unckell F, Werr M, Streeck RE. Analysis ofintermolecular disulfide bonds and free sulfhydryl groups
in hepatitis B surface antigen particles.Arch Virol 1997;142:2257-2267
6 Xu Z, Bruss V, Yen TS. Formation of intracellular particles byhepatitis B virus large surface protein. J Virol
1997;71:5487-5494
, http://www.100md.com
7 成军,杨守纯. 现代肝炎病毒分子生物学. 第1版.北京: 人民军医出版社, 1997:25-43
8 金奇. 医学分子病毒学. 第1版. 北京:科学出版社, 2001:334-335
9 Alka S, Hemlata D, Vaishali C, Shahid J, Kumar PS, Hepatitis B virus surface(S) transactivator with DNA-binding
properties. J Med Virol 2000;61:1-10
10 De Meyer S, Depla E, Maertens G, Soumillion A, Yap SH. Characterization ofsmall hepatitis B surface antigen
, 百拇医药
epitopes involved in binding to humanannexin V. J Viral Hepat 1999;6: 277285
11 Lu CC, Chen M, Ou JH, Yen TS. Key role of a CCAAT element inregulating hepatitis B virus surface protein
expression. Virology 1995;206:1155-1158
12 季伟,王慧芬.乙型肝炎病毒转录后调节机制的研究进展.国外医学.流行病学传染病学分册2000;27:120-124
13 吴炜,李兰娟. HBV前S基因变异及其临床意义.国外医学.流行病学传染病学分册 2002;29:200-202
, 百拇医药
14 Bock CT, Kubicka S, Manns MP, Trautwein C. Two control elements in the hepatitis B virus S-promoter are important
for full promtoter activity mediated by CCAAT-binding factor. Hepatology 1999;29:1236-1247
15 Bock CT, Tillmann HL, Manns MP, Trautwein C. The pre-S region determines the intracellular localization and
appearance of hepatitis B virus. Hepatology 1999; 30:517-525
, http://www.100md.com
16 Bock CT, Tillmann HL, Maschek HJ, Manns MP, Trautwein C. A preS mutation isolated from a patient with chronic
hepatitis B infection leads to virus retention and misassembly.Gastroenterology 1997;113:1976-1982
17 Ha-Lee YM, Lee J, Pyun H, Kim Y, Sohn J, Cho YJ, Kim Y. Sequencevariations of hepatitis B virus promoter regions
in persistently infected patients. Arch Virol 2001;146:279-292
, http://www.100md.com
18 Kajiya Y, Hamasaki K, Nakata K, Nakagawa Y, Miyazoe S, Takeda Y, Ohkubo K, Ichikawa T, Nakao K, Kato Y, Eguchi
K. Full-length sequence and functionalanalysis of hepatitis B virus genome in a virus carrier:a case reportsuggesting
the impact of pre-S and core promotermutations on the progression of the disease. J Viral Hepat 2002;9:149-156
19 Raney AK, McLachlan A. Characterization of the hepatitis B virusmajor surface antigen promoter hepatocyte nuclear
, http://www.100md.com
factor 3 binding site. J Gen Virol 1997;78:3029-3038
20 Li J, Ou JH. Differential regulation of hepatitis B virus gene expression by the SP1 transcription factor. J Virol
2001;75: 8400-8406
21 Bogomolski-Yahalom V, Klein A, Greenblat I, Haviv Y, Tur-Kaspa R. The TATA-less promoterof hepatitis B virus S
gene contains a TBP binding site and anactive initiator. Virus Res 1997;49:1-7, http://www.100md.com( 梁耀东, 成 军, 陆荫英, 吴 君, 程明亮)
