乙型和丙型肝炎病毒对细胞周期素及细胞周期素依赖性蛋白激酶的调节
成军,刘妍, 洪源,王建军, 杨倩,中国人民解放军第302医院传染病研究所基因治疗研究中心,全军病毒性肝炎防治研究重点实验室 北京市 100039
国家自然科学基金攻关项目,No. C03011402, No. C30070689
军队“九、五”科技攻关项目,No. 98D063
军队回国留学人员启动基金项目,No.98H038
军队“十、五”科技攻关青年基金项目,No. 01Q138
军队“十、五”科技攻关面上项目,No. 01MB135
项目负责人:成军, 100039, 北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心,全军病毒性肝炎防治研究重点实验室. cj@genetherapy.com.cn
, 百拇医药
电话:010-66933391 传真:010-63801283
收稿日期:2003-03-08 接受日期:2003-04-16
成军,刘妍, 洪源,王建军, 杨倩.乙型和丙型肝炎病毒对细胞周期素及细胞周期素依赖性蛋白激酶的调节.世界华人消化杂志 2003;11(8):1255-1258
Hoppe-Seyler F, Crnkovic-Mertens I, Denk C, Fitscher BA, Klevenz B,Tomai E, Butz K. Peptide aptamers: new tools to
study protein interactions. J SteroidBiochem Mol Biol 2001;78:105-111
, 百拇医药
2 Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A isrequired at two points in the human cell cycle.
EMBO J 1992;11:961-971
3 Chuang SE, Cheng AL, Lin JK, Kuo ML. Inhibition by curcumin ofdiethylnitrosamine-induced hepatic
hyperplasia, inflammation, cellular geneproducts and cell-cycle-related proteins in rats. Food Chem
Toxicol 2000;38:991-995
, 百拇医药
4 Chuang SE, Kuo ML, Hsu CH, Chen CR, Lin JK, Lai GM, Hsieh CY, ChengAL. Curcumin-containing diet
inhibits diethylnitrosamine-induced murinehepatocarcinogenesis. Carcinogenesis 2000;21:331-335
5 Ramljak D, Jones AB, Diwan BA, Perantoni AO, Hochadel JF, AndersonLM. Epidermal growth factor and
transforming growth factor-alpha-associatedoverexpression of cyclin D1, CDK4, and c-Myc during
, 百拇医药
hepatocarcinogenesis in Helicobacterhepaticus-infected A/JCr mice. Cancer Res 1998;58:3590-3597
6 Kohzato N, Dong Y, Sui L, Masaki T, Nagahata S, Nishioka M, KonishiR, Tokuda M. Overexpression of cyclin E
and cyclin-dependent kinase 2 is correlatedwith development of hepatocellular carcinomas. Hepatol Res
2001;21:27-39
7 Kim H, Lee MJ, Kim MR, Chung IP, Kim YM, Lee JY, Jang JJ.Expression of cyclin D1, cyclin E, CDK4 and loss
, http://www.100md.com
of heterozygosity of 8p, 13q, 17p inhepatocellular carcinoma: comparison study of childhood and adult
hepatocellular carcinoma. Liver 2000;20:173-178
8 Masaki T, Shiratori Y, Rengifo W, Igarashi K, Matsumoto K, NishiokaM, Hatanaka Y, Omata M. Hepatocellular carcinoma
cell cycle: study of Long-Evans cinnamonrats. Hepatology 2000;32:711-720
9 Yeh CT, Lu SC, Chen TC, Peng CY, Liaw YF. Aberrant transcripts ofthe cyclin-dependent kinase-associated
, 百拇医药
protein phosphatase in hepatocellularcarcinoma. Cancer Res 2000;60:4697-4700
10 Lee MN, Jung EY, Kwun HJ, Jun HK, Yu DY, Choi YH, Jang KL.Hepatitis C virus core protein represses the p21
promoter through inhibition of a TGF-betapathway. J Gen Virol 2002;83:2145-2151
11 Bouchard M, Giannakopoulos S, Wang EH, Tanese N, Schneider RJ.Hepatitis B virus HBx protein activation of
, http://www.100md.com
cyclin A-cyclin-dependent kinase 2complexes and G1 transit via a Src kinase pathway. J Virol 2001;75:4247-4257
12 Benn J, Schneider RJ. Hepatitis B virus HBx protein deregulatescell cycle checkpoint controls. Proc Natl Acad Sci
USA 1995;92:11215-11219
13 Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J,Wissing J, Ullrich A, Cotten M. Identification of
, http://www.100md.com
SRPK1 and SRPK2 as the major cellularprotein kinases phosphorylating hepatitis B virus core protein. J
Virol 2002;76:8124-8137
14 Barrasa MI, Guo JT, Saputelli J, Mason WS, Seeger C. Does a cdc2kinase-like recognition motif on the core protein
of hepadnaviruses regulate assembly anddisintegration of capsids? J Virol 2001;75:2024-2028
15 Cho JW, Baek WK, Suh SI, Yang SH, Chang J, Sung YC, Suh MH.Hepatitis C virus core protein promotes cell
, 百拇医药
proliferation through the upregulation ofcyclin E expression levels. Liver 2001;21:137-142
16 Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM.Hepatitis B virus X protein differentially regulates cell
cycle progression in X-transforming versusnontransforming hepatocyte (AML12) cell lines. J Biol Chem
2002;277:8730-8740
17 Han HJ, Jung EY, Lee WJ, Jang KL. Cooperative repression of cyclin-dependentkinase inhibitor p21 gene expression
, 百拇医药
by hepatitis B virus X protein andhepatitis C virus core protein. FEBS Lett 2002;518:169-172
18 Yoshida I, Oka K, Hidajat R, Nagano-Fujii M, Ishido S, Hotta H.Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis
C virus core protein. Microbiol Immunol 2001;45:689-697
19 Park US, Park SK, Lee YI, Park JG, Lee YI. Hepatitis B virus-Xprotein upregulates the expression of p21waf1/cip1
, 百拇医药
and prolongs G1>S transition via ap53-independent pathway in human hepatoma cells. Oncogene
2000;19:3384-3394
20 Crary GS, Albrecht JH. Expression of cyclin-dependent kinaseinhibitor p21 in human liver. Hepatology
1998;28:738-743
21 Berasain C, Patil D, Perara E, Huang SM, Mouly H, Brechot C.Oncogenic activation of a human cyclin A2 targeted to
, http://www.100md.com
the endoplasmic reticulum upon hepatitis Bvirus genome insertion. Oncogene 1998;16:1277-1288
22 Zafrullah M, Ozdener MH, Panda SK, Jameel S. The ORF3 protein ofhepatitis E virus is a phosphoprotein that
associates with the cytoskeleton. J Virol 1997;71:9045-9053
23 Wolowiec D, Ffrench M. Cyclins A and B: redundancy and specificity.Pathol Biol (Paris) 1993;41:547-553
24 Wolowiec D, Ffrench M. Mitotic cyclins-new possibilities forexamining mechanisms of neoplasm growth. Postepy Hig
Med Dosw 1993;47:183-191, 百拇医药( 成 军, 刘 妍, 洪 源, 王建军, 杨 倩)
国家自然科学基金攻关项目,No. C03011402, No. C30070689
军队“九、五”科技攻关项目,No. 98D063
军队回国留学人员启动基金项目,No.98H038
军队“十、五”科技攻关青年基金项目,No. 01Q138
军队“十、五”科技攻关面上项目,No. 01MB135
项目负责人:成军, 100039, 北京市西四环中路100号,中国人民解放军第302医院传染病研究所基因治疗研究中心,全军病毒性肝炎防治研究重点实验室. cj@genetherapy.com.cn
, 百拇医药
电话:010-66933391 传真:010-63801283
收稿日期:2003-03-08 接受日期:2003-04-16
成军,刘妍, 洪源,王建军, 杨倩.乙型和丙型肝炎病毒对细胞周期素及细胞周期素依赖性蛋白激酶的调节.世界华人消化杂志 2003;11(8):1255-1258
Hoppe-Seyler F, Crnkovic-Mertens I, Denk C, Fitscher BA, Klevenz B,Tomai E, Butz K. Peptide aptamers: new tools to
study protein interactions. J SteroidBiochem Mol Biol 2001;78:105-111
, 百拇医药
2 Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A isrequired at two points in the human cell cycle.
EMBO J 1992;11:961-971
3 Chuang SE, Cheng AL, Lin JK, Kuo ML. Inhibition by curcumin ofdiethylnitrosamine-induced hepatic
hyperplasia, inflammation, cellular geneproducts and cell-cycle-related proteins in rats. Food Chem
Toxicol 2000;38:991-995
, 百拇医药
4 Chuang SE, Kuo ML, Hsu CH, Chen CR, Lin JK, Lai GM, Hsieh CY, ChengAL. Curcumin-containing diet
inhibits diethylnitrosamine-induced murinehepatocarcinogenesis. Carcinogenesis 2000;21:331-335
5 Ramljak D, Jones AB, Diwan BA, Perantoni AO, Hochadel JF, AndersonLM. Epidermal growth factor and
transforming growth factor-alpha-associatedoverexpression of cyclin D1, CDK4, and c-Myc during
, 百拇医药
hepatocarcinogenesis in Helicobacterhepaticus-infected A/JCr mice. Cancer Res 1998;58:3590-3597
6 Kohzato N, Dong Y, Sui L, Masaki T, Nagahata S, Nishioka M, KonishiR, Tokuda M. Overexpression of cyclin E
and cyclin-dependent kinase 2 is correlatedwith development of hepatocellular carcinomas. Hepatol Res
2001;21:27-39
7 Kim H, Lee MJ, Kim MR, Chung IP, Kim YM, Lee JY, Jang JJ.Expression of cyclin D1, cyclin E, CDK4 and loss
, http://www.100md.com
of heterozygosity of 8p, 13q, 17p inhepatocellular carcinoma: comparison study of childhood and adult
hepatocellular carcinoma. Liver 2000;20:173-178
8 Masaki T, Shiratori Y, Rengifo W, Igarashi K, Matsumoto K, NishiokaM, Hatanaka Y, Omata M. Hepatocellular carcinoma
cell cycle: study of Long-Evans cinnamonrats. Hepatology 2000;32:711-720
9 Yeh CT, Lu SC, Chen TC, Peng CY, Liaw YF. Aberrant transcripts ofthe cyclin-dependent kinase-associated
, 百拇医药
protein phosphatase in hepatocellularcarcinoma. Cancer Res 2000;60:4697-4700
10 Lee MN, Jung EY, Kwun HJ, Jun HK, Yu DY, Choi YH, Jang KL.Hepatitis C virus core protein represses the p21
promoter through inhibition of a TGF-betapathway. J Gen Virol 2002;83:2145-2151
11 Bouchard M, Giannakopoulos S, Wang EH, Tanese N, Schneider RJ.Hepatitis B virus HBx protein activation of
, http://www.100md.com
cyclin A-cyclin-dependent kinase 2complexes and G1 transit via a Src kinase pathway. J Virol 2001;75:4247-4257
12 Benn J, Schneider RJ. Hepatitis B virus HBx protein deregulatescell cycle checkpoint controls. Proc Natl Acad Sci
USA 1995;92:11215-11219
13 Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J,Wissing J, Ullrich A, Cotten M. Identification of
, http://www.100md.com
SRPK1 and SRPK2 as the major cellularprotein kinases phosphorylating hepatitis B virus core protein. J
Virol 2002;76:8124-8137
14 Barrasa MI, Guo JT, Saputelli J, Mason WS, Seeger C. Does a cdc2kinase-like recognition motif on the core protein
of hepadnaviruses regulate assembly anddisintegration of capsids? J Virol 2001;75:2024-2028
15 Cho JW, Baek WK, Suh SI, Yang SH, Chang J, Sung YC, Suh MH.Hepatitis C virus core protein promotes cell
, 百拇医药
proliferation through the upregulation ofcyclin E expression levels. Liver 2001;21:137-142
16 Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM.Hepatitis B virus X protein differentially regulates cell
cycle progression in X-transforming versusnontransforming hepatocyte (AML12) cell lines. J Biol Chem
2002;277:8730-8740
17 Han HJ, Jung EY, Lee WJ, Jang KL. Cooperative repression of cyclin-dependentkinase inhibitor p21 gene expression
, 百拇医药
by hepatitis B virus X protein andhepatitis C virus core protein. FEBS Lett 2002;518:169-172
18 Yoshida I, Oka K, Hidajat R, Nagano-Fujii M, Ishido S, Hotta H.Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis
C virus core protein. Microbiol Immunol 2001;45:689-697
19 Park US, Park SK, Lee YI, Park JG, Lee YI. Hepatitis B virus-Xprotein upregulates the expression of p21waf1/cip1
, 百拇医药
and prolongs G1>S transition via ap53-independent pathway in human hepatoma cells. Oncogene
2000;19:3384-3394
20 Crary GS, Albrecht JH. Expression of cyclin-dependent kinaseinhibitor p21 in human liver. Hepatology
1998;28:738-743
21 Berasain C, Patil D, Perara E, Huang SM, Mouly H, Brechot C.Oncogenic activation of a human cyclin A2 targeted to
, http://www.100md.com
the endoplasmic reticulum upon hepatitis Bvirus genome insertion. Oncogene 1998;16:1277-1288
22 Zafrullah M, Ozdener MH, Panda SK, Jameel S. The ORF3 protein ofhepatitis E virus is a phosphoprotein that
associates with the cytoskeleton. J Virol 1997;71:9045-9053
23 Wolowiec D, Ffrench M. Cyclins A and B: redundancy and specificity.Pathol Biol (Paris) 1993;41:547-553
24 Wolowiec D, Ffrench M. Mitotic cyclins-new possibilities forexamining mechanisms of neoplasm growth. Postepy Hig
Med Dosw 1993;47:183-191, 百拇医药( 成 军, 刘 妍, 洪 源, 王建军, 杨 倩)
