paxillin在胃腺癌中的表达及临床意义
田素芳,熊永炎, 余少平,汪必成,武汉大学中南医院病理科 湖北省武汉市 430071
项目负责人:熊永炎,430071, 湖北省武汉市东湖路169号,武汉大学中南医院病理科.
电话:027-67813159
收稿日期:2002-11-12 接受日期:2002-11-29
摘要
目的:研究焦点黏附相关调节蛋白paxillin在胃癌组织中的表达及其与胃癌细胞分化、浸润及转移的关系.
方法:应用免疫组化SP法检测80例胃癌和40例淋巴结转移灶中paxillin的表达情况.
结果:paxillin在胃中、低分化腺癌组织中的表达显著高于高分化腺癌,进展期胃癌组织中显著高于早期胃癌,胃癌原发灶中显著高于淋巴结转移灶.
结论:paxillin可能在胃癌细胞的分化、浸润和转移中起着重要作用.
田素芳,熊永炎, 余少平,汪必成.paxillin在胃腺癌中的表达及临床意义.世界华人消化杂志 2003;11(10):1632-1634
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