龚作炯,宋仕玲, 阮鹏,向龙奎, 张志荣,武汉大学病毒学教育部重点实验室,武汉大学人民医院感染科 湖北省武汉市 430060

    龚作炯,男, 1962-12-01生,湖北省云梦市人,汉族, 1996年比利时鲁汶大学医学院博士,1996-1998年比利时鲁汶大学医学院博士后,现任武汉大学人民医院感染科主任,教授, 博士生导师.主要从事病毒性肝炎的基础与临床研究.

    项目负责人:龚作炯,430060, 湖北省武汉市,武汉大学病毒学教育部重点实验室,武汉大学人民医院感染科. zjgong@163.com

    电话:027-88041911-8385 传真:027-88042922

    收稿日期:2003-12-19 接受日期:2004-01-15

    Effects of angiotensin-converting enzyme inhibitor on expression of TGFb1and TGFRⅡmRNA, Smad3 and Smad7 on CCl4-inducing rat hepatic fibrogenesis

    Zuo-JiongGong, Shi-Ling Song, Peng Ruan, Long-Kui Xiang, Zhi-Rong Zhang

    Zuo-Jiong Gong, Shi-Ling Song, Peng Ruan, Long-Kui Xiang, Zhi-Rong Zhang,Key Laboratory of Virology for Ministeryof Education. Department of Infectious Diseases, Renmin Hospital, WuhanUniversity, Wuhan 430060, China

    Correspondence to: Dr. Zuo-Jiong Gong, Department of InfectiousDiseases, Renmin Hospital, Wuhan University, Wuhan 430060, China. zjgong@163.com

    Received: 2003-12-19 Accepted:2004-01-15

    AbstractAIM: To assess the effects of an angiotensin-converting enzymeinhibitor, perindopril on preventing hepatic fibrosis induced by CCl₄in rats and to investigate the alternation of the expression oftransforming growth factor-beta1 (TGFb1)and its receptor Ⅱ (TGFRⅡ) and smads on liver tissues. ......