螺内酯对大鼠肝纤维化及TGFb1 TIMP-1表达的作用
螺内酯对大鼠肝纤维化及TGFb1TIMP-1表达的作用,黄欣,朱纲,王磊,项目负责人,:,Effectsofspironolactoneonratliverfibrosisandexpressionoftransforminggrowthfactorb1andtissueinhibitorofmetalloproteinase-1,Correspondenceto:,Abstract,摘要,目的,:,方法,结果,结论,0,引言,1
黄欣,朱纲, 王磊,上海市第九人民医院消化内科 上海市 200011黄欣,女, 1973-07-19生,福建省莆田市人,汉族, 主治医师.
项目负责人:黄欣, 200011, 上海市第九人民医院消化内科. huangx201@sina.com.cn
收稿日期:2004-03-26 接受日期:2004-04-15
Effects of spironolactone on rat liver fibrosis and expression oftransforming growth factor b1and tissue inhibitor of metalloproteinase-1
Xin Huang,Gang Zhu, Lei Wang
Xin Huang, Gang Zhu, Lei Wang, Department of Gastroenterology, NinthPeople's Hospital,Shanghai Second Medical University, Shanghai 200011, China
Correspondence to: Xin Huang, Department of Gastroenterology, NinthPeople's Hospital,Shanghai Second Medical University, Shanghai 200011, China. huangx201@sina.com.cn
Received: 2004-03-26 Accepted:2004-04-15
AbstractAIM: To identify the effects of spironolactone on expressions oftransforming growth factor b1and tissue inhibitor of metalloproteinase-1 and to evaluate the curativeeffect of spironolactone.
METHODS: Thirty four male SD rats were randomly divided into 3 groups:Hepatic fibrosis model group: the rats were injected with 400 mL/L CCl43 mL/kg subcutaneously two times a week; Spironolactone group: the ratswere injected with 400 mL/L CCl4 3 mL/kg subcutaneously twotimes a week; Spironolactone equivalent to 20 mg/kg per day was givenintragastrically; Normal control group: normal chow. Hepatic tissue wasobserved with light microscopy to compare histological alterationsdynamically. The expression of transforming growth factor b1and tissue inhibitor of metalloproteinase-1 was detected by RT-PCR. ......
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