王娟,中国人民解放军总医院消化科 北京市 100853

    杨昭徐,崔培林, 首都医科大学附属北京天坛医院消化科 北京市 100050

    王娟,女, 1968-12-03生,陕西省白水县人,汉族, 1991年山东医科大学医疗系毕业,主治医师, 主要从事胃肠功能性疾病的临床研究.

    项目负责人:王娟, 100853, 北京市复兴路28号,中国人民解放军总医院消化科.

    电话:010-68154653 传真:010-68154653

    收稿日期:2004-04-28 接受日期:2004-06-17

    Preventive effect of hydrotalcite on stressulcer in rats after acute brain trauma

    JuanWang, Zhao-Xu Yang, Pei-Lin Cui

    Juan Wang, Department of Gastroenterology, Chinese PLA General Hospital,Beijing 100853, China

    Zhao-Xu Yang, Pei-Lin Cui, Department of Gastroenterology, Beijing TiantanHospital, Capital University of Medical Sciences, Beijing 100050, China

    Correspondence to: Juan Wang, Department of Gastroenterology,Chinese PLA General Hospital, Beijing 100853, China.

    Received: 2004-04-28 Accepted:2004-06-17

    AbstractAIM: To study the role of bile reflux in the stress ulcer in ratsafter acute brain trauma, and to investigate the preventive role ofHydrotalcite (Talcid) to the stress ulcer.

    METHODS: An animal model was established by Allen’smethod with modification. 128 male Wistar rats were divided randomly intofour groups: Group I (n =32): stress ulcer group, rats sufferedfrom acute brain trauma without therapy; Group II (n =32): normalcontrol group, rats with sham operation; Group III (n =32): Talcidgroup, rats suffered from acute brain trauma with Talcid administration;Group IV (n =32): normal saline (NS) group, rats suffered fromacute brain trauma with NS administration. Each group was divided intofour subgroups of 1 h, 3 h, 6 h, and 24 h after the trauma (n =8,for each subgroup). The rats in groups III and IV received Talcid and NSby gavage respectively before the operation for three days (Talcid: 500mg/kg.weight/day,NS: 1.5 mL/kg. weight/day). The bile acid concentration in the stomach andblood, the PH value and ulcer index (UI) were assayed, and the histologyof gastric mucosa was analysed. ......