依那普利对大鼠肝纤维化的预防和治疗作用
柳怿,李继强,项目负责人,:,Preventiveandtherapeuticeffectsofenalaprilonliverfibrosisinrats,Correspondenceto:,Abstract,摘要,目的,:,方法,结果,结论,0,引言,1,材料和方法,1.1材料,1.2,统计学处理,2,结果,2.1大鼠死亡率和体质量,2.
柳怿,李继强,上海市消化疾病研究所,上海第二医科大学附属仁济医院消化科 上海市 200001柳怿,女, 1973-10-19生,上海市人, 汉族.1996年上海第二医科大学本科毕业,现为上海第二医科大学在读博士研究生.主要从事肝脏疾病的研究.
项目负责人:李继强,200001, 上海市山东中路145号,上海市消化疾病研究所,上海第二医科大学附属仁济医院消化科. leejiqiang@21cn.com
电话:021-63200874 传真:021-63266027
收稿日期:2004-05-07 接受日期:2004-06-24
Preventive and therapeutic effects of enalapril on liver fibrosis inrats
Yi Liu, Ji-Qiang Li
Yi Liu, Ji-Qiang Li, Shanghai Institute of Digestive Disease, ShanghaiSecond Medical University Renji Hospital, Shanghai 200001, China
Correspondence to: Dr. Ji-Qiang Li, Shanghai Institute of DigestiveDisease, 145 Shandong Middle Road, Shanghai 200001, China. leejiqiang@21cn.com
Received: 2004-05-07 Accepted:2004-06-24
AbstractAIM: To study the effects of angiotensin-converting enzyme inhibitor,enalapril, on the extent of liver fibrosis in experimental fibrotic ratsinduced by carbon tetrachloride (CCl4).
METHODS: Liver fibrosis in rats was induced by CCl4. Rats wereassigned into control group, model group, prevention groups and treatmentgroups. Except for rats in control group, all rats were given subcutaneousinjection of 400 mL/L CCl4, once every 3 days for 10 weeks.Rats in prevention groups were also given enalapril via gastrogavage. Butrats in treatment groups were given enalapril from the fifth week to theend via gastrogavage. At the end of tenth week, livers and spleens weremeasured and specimens of liver were stored. The extent of liverinflammation and fibrosis was evaluated with HE and Masson staining. Wealso observed the ultrastructures of hepatocytes under electronmicroscope. ......
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