慢性应激大鼠结肠黏膜NO含量变化的意义
仝巧云,罗和生,陈敏,项目负责人,:,Changesofnitricoxideincolonicmucosaofratssubmittedtochronicstress,Correspondenceto:,Abstract,摘要,目的,方法,结果,结论,0,引言,1,材料和方法,1.1材料,1.2,统计学处理,2,结果,2.1炎性细胞计数,2.
仝巧云,罗和生, 陈敏,武汉大学人民医院消化内科 湖北省武汉市 430060仝巧云,女,1968-10-25生, 河南洛阳人,汉族, 1992年同济医科大学本科毕业,武汉大学医学院2003级硕士研究生,研究方向胃肠道疾病基础与临床.
项目负责人:罗和生,430060, 湖北省武汉市解放路238号,武汉大学人民医院消化内科. luotang@public.wh.hb.cn
电话:027-88041919-2135
收稿日期:2004-06-16 接受日期:2004-08-05
Changes of nitric oxide in colonic mucosa of rats submitted to chronicstress
Qiao-Yun Tong, He-Sheng Luo, Min Chen
Qiao-Yun Tong, He-Sheng Luo, Min Chen, Department of Gastroenterology,Renmin hospital of Wuhan University,Wuhan 430060, Hubei Province ,China
Correspondence to: Dr. He-Sheng Luo, Department of Gastroenterology, Renmin hospital of Wuhan University, 238 JiefangRoad, Wuhan 430060, Hubei Province,China. luotang@public.wh.hb.cn
Received: 2004-06-16 Accepted:2004-08-05
AbstractAIM: To investigate the changes of nitric oxide (NO) in the colonicmucosa of rats submitted to chronic stress and to study the mechanism ofchronic stress damage to colonic mucosa.
METHODS: Thirty Wistar rats were randomly divided into control group (n=10), stress group (n =10), stress and injection aminoguanidinegroup (n =10). The latter two groups were submitted toimmobilization stress 2 h/d for 14 days. The numbers of the inflammatorycells and ultrastructural damage of colon epithelial cells were observedunder light and electron microscopes respectively. The concentration of NOand iNOS were measured by chemical methods. ......
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