干扰素对肝星状细胞活化的影响
饶慧瑛, 魏来, 北京大学人民医院肝病研究所 北京市 100044
饶慧瑛,女, 1978-02-24生, 江西南城人, 汉族, 主要从事肝纤维化及丙型肝炎的研究.
项目负责人:饶慧瑛, 100044, 北京市, 北京大学人民医院肝病研究所.
rao.huiying@163.com
电话: 010-68314422
收稿日期: 2004-12-31 接受日期: 2005-01-20
, 百拇医药
摘要
干扰素分为两大类:I型和II型.I型干扰素分为IFN-a、IFN-b、IFN-w，II型干扰素IFN-g.IFN结合细胞表面特殊的受体.IFN-a、IFN-b竞争结合细胞表面相同的受体，而IFN-g结合不同的受体，干扰素的受体本身并无酪氨酸激酶活性，但也可以激活酪氨酸激酶通路，将信号有细胞表面而传导至核而影响特异的基因转录等一系列细胞内事件.IFN-a已经显示在各种类型的间质细胞中有抗增生和抗纤维化作用.IFN-b可能更容易诱导细胞凋亡，另外可以减少a-SMA表达，从而减轻肝纤维化.IFN-g是肝纤维化发展中一个关键的调节因子，通过抑制肝星状细胞的活化，拮抗TGF-b1，诱导胶原酶产生而降低细胞外基质的沉积.
关键词:干扰素; 肝星状细胞; 胶原纤维
饶慧瑛, 魏来. 干扰素对肝星状细胞活化的影响. 世界华人消化杂志 2005;13(4):440-442
, 百拇医药
Iredale JP. Hepatic stellate cell behavior during resolution ofliver injury. Semin Liver Dis 2001;21:427-436
2 Pinzani M, Gentilini P. Biology of hepatic stellate cells and theirpossible relevance in the pathogenesis of portal
hypertension in cirrhosis. Semin LiverDis 1999;19:397-410
3 Li D, Friedman SL. Liver fibrogenesis and the role of hepaticstellate cells: new insights and prospects for therapy.
, 百拇医药
J Gastroenterol Hepatol 1999;14:618-633
4 Darnell JE, Kerr IM, Stark GR. Jack-STAT pathways andtranscriptional activation inrespones to IFNs and other
extracellular signaling proteins. Science 1994;264:1415-1421
5 Uze G, Lutfalla G, Morgensen KE. Alpha and beta interferon andtheir receptor and their friends and relations.
J Interferon Cytokine Res 1995;15:3-26
, 百拇医药
6 Dearolf CR. JAKs and STATs in invertebrate model organisms. CellMol Life Sci 1999;55:1578-1584
7 Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, KawadaN, Shirasaki F, Takehara K, Sugiyama K,Fujii M, Yamauchi H, Nakao A, deCrombrugghe B, Watanabe T, Okazaki I. Interferon alfa down-regulatescollagen
gene transcription and suppressesexperimental hepatic fibrosis in mice. Hepatology 2003;38:890-899
, 百拇医药
8 Lu G, Shimizu I, Cui X, Itonaga M, Tamaki K, Fukuno H, Inoue H,Honda H, Ito S. Interferon-alpha enhances biological
defense activities against oxidative stressin cultured rat hepatocytes and hepatic stellate cells. J Med Invest
2002;49:172-181
9 Vendemiale G, Grattagliano I, Caruso ML, Serviddio G, Valentini AM,Pirrelli M, Altomare E. Increased oxidative stress
, 百拇医药
in dimethylnitrosamine-induced liverfibrosis in the rat:effect of N-acetylcysteine and interferon-alpha.
Toxicol Appl Pharmacol 2001;175:130-139
10 Saile B, Eisenbach C, El-Armouche H, Neubauer K, Ramadori G.Antiapoptotic effect of interferon-alpha on hepatic
stellate cells(HSC): a novel pathwayof IFN-alpha signal transduction via Janus kinase 2(JAK2)and caspase-8.
, 百拇医药
Eur J Cell Biol 2003;82:31-41
11 Watanabe T, Niioka A, Ishikawa A, Hozawa S, Arai M, Maruyama K,Okada A, Okazaki I. Dynamic of cells expressing
MMP-2 mRNA and MT1-MMP mRNA in therecovery from liver fibrosis in the rat. J Hepatol 2001;35:465-473
12 Sakaida I, Nagatomi A, Hironaka K, Uchida K, Okita K. Quantitativeanalysis of liver fibrosis and stellate cell changes
, http://www.100md.com
in patients with chronic hepatitis Cafter interferon therapy. Am J Gastroenterol 1999;94:489-496
13 Platanias LC, Uddin S, Domanski P, Colamonici OR. Differences ininterferon alpha and beta signaling. Interferon
beta selectively induces theinteraction of the alpha and betaL subunits of the type 1 interferonreceptor.
J Biol Chem 1996;271:23630-23633
14 Shen H, Zhang M, Minuk GY, Gong Y. Different effects of ratinterferon alpha, beta and gamma on rat hepatic stellate
, 百拇医药
cell. BMC Cell Biol 2002;3:9-13
15 Baroni GS, D'Ambrosio L, Curto P, Casini A, Mancini R, Jezequel AM,Benedetti A. Interferon gamma decreases
hepatic stellate cell activation andextracellular matrix deposition in rat liver fibrosis. Hepatology 1996;23:1189-1199
16 Shibata N, Watanabe T, Okitsu T, Sakaguchi M, Takesue M, Kunieda T,Omoto K, Yamamoto S, Tanaka N,Kobayashi N. Establishment of animmortalized human hepatic stellate cell line to develop antifibrotictherapies.
, http://www.100md.com
Cell Transplant 2003;12:499-507
17 Saile B, Eisenbach C, Dudas J, El-Armouche H, Ramadori G.Interferon-gamma acts proapoptotic on hepatic stellate
cells(HSC)and abrogates theantiapoptotic effect of interferon-alpha by an HSP70-dependant pathway.
Eur J Cell Biol 2004;83:469-476
编辑 张海宁, 百拇医药( 饶慧瑛,魏 来)
饶慧瑛,女, 1978-02-24生, 江西南城人, 汉族, 主要从事肝纤维化及丙型肝炎的研究.
项目负责人:饶慧瑛, 100044, 北京市, 北京大学人民医院肝病研究所.
rao.huiying@163.com
电话: 010-68314422
收稿日期: 2004-12-31 接受日期: 2005-01-20
, 百拇医药
摘要
干扰素分为两大类:I型和II型.I型干扰素分为IFN-a、IFN-b、IFN-w，II型干扰素IFN-g.IFN结合细胞表面特殊的受体.IFN-a、IFN-b竞争结合细胞表面相同的受体，而IFN-g结合不同的受体，干扰素的受体本身并无酪氨酸激酶活性，但也可以激活酪氨酸激酶通路，将信号有细胞表面而传导至核而影响特异的基因转录等一系列细胞内事件.IFN-a已经显示在各种类型的间质细胞中有抗增生和抗纤维化作用.IFN-b可能更容易诱导细胞凋亡，另外可以减少a-SMA表达，从而减轻肝纤维化.IFN-g是肝纤维化发展中一个关键的调节因子，通过抑制肝星状细胞的活化，拮抗TGF-b1，诱导胶原酶产生而降低细胞外基质的沉积.
关键词:干扰素; 肝星状细胞; 胶原纤维
饶慧瑛, 魏来. 干扰素对肝星状细胞活化的影响. 世界华人消化杂志 2005;13(4):440-442
, 百拇医药
Iredale JP. Hepatic stellate cell behavior during resolution ofliver injury. Semin Liver Dis 2001;21:427-436
2 Pinzani M, Gentilini P. Biology of hepatic stellate cells and theirpossible relevance in the pathogenesis of portal
hypertension in cirrhosis. Semin LiverDis 1999;19:397-410
3 Li D, Friedman SL. Liver fibrogenesis and the role of hepaticstellate cells: new insights and prospects for therapy.
, 百拇医药
J Gastroenterol Hepatol 1999;14:618-633
4 Darnell JE, Kerr IM, Stark GR. Jack-STAT pathways andtranscriptional activation inrespones to IFNs and other
extracellular signaling proteins. Science 1994;264:1415-1421
5 Uze G, Lutfalla G, Morgensen KE. Alpha and beta interferon andtheir receptor and their friends and relations.
J Interferon Cytokine Res 1995;15:3-26
, 百拇医药
6 Dearolf CR. JAKs and STATs in invertebrate model organisms. CellMol Life Sci 1999;55:1578-1584
7 Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, KawadaN, Shirasaki F, Takehara K, Sugiyama K,Fujii M, Yamauchi H, Nakao A, deCrombrugghe B, Watanabe T, Okazaki I. Interferon alfa down-regulatescollagen
gene transcription and suppressesexperimental hepatic fibrosis in mice. Hepatology 2003;38:890-899
, 百拇医药
8 Lu G, Shimizu I, Cui X, Itonaga M, Tamaki K, Fukuno H, Inoue H,Honda H, Ito S. Interferon-alpha enhances biological
defense activities against oxidative stressin cultured rat hepatocytes and hepatic stellate cells. J Med Invest
2002;49:172-181
9 Vendemiale G, Grattagliano I, Caruso ML, Serviddio G, Valentini AM,Pirrelli M, Altomare E. Increased oxidative stress
, 百拇医药
in dimethylnitrosamine-induced liverfibrosis in the rat:effect of N-acetylcysteine and interferon-alpha.
Toxicol Appl Pharmacol 2001;175:130-139
10 Saile B, Eisenbach C, El-Armouche H, Neubauer K, Ramadori G.Antiapoptotic effect of interferon-alpha on hepatic
stellate cells(HSC): a novel pathwayof IFN-alpha signal transduction via Janus kinase 2(JAK2)and caspase-8.
, 百拇医药
Eur J Cell Biol 2003;82:31-41
11 Watanabe T, Niioka A, Ishikawa A, Hozawa S, Arai M, Maruyama K,Okada A, Okazaki I. Dynamic of cells expressing
MMP-2 mRNA and MT1-MMP mRNA in therecovery from liver fibrosis in the rat. J Hepatol 2001;35:465-473
12 Sakaida I, Nagatomi A, Hironaka K, Uchida K, Okita K. Quantitativeanalysis of liver fibrosis and stellate cell changes
, http://www.100md.com
in patients with chronic hepatitis Cafter interferon therapy. Am J Gastroenterol 1999;94:489-496
13 Platanias LC, Uddin S, Domanski P, Colamonici OR. Differences ininterferon alpha and beta signaling. Interferon
beta selectively induces theinteraction of the alpha and betaL subunits of the type 1 interferonreceptor.
J Biol Chem 1996;271:23630-23633
14 Shen H, Zhang M, Minuk GY, Gong Y. Different effects of ratinterferon alpha, beta and gamma on rat hepatic stellate
, 百拇医药
cell. BMC Cell Biol 2002;3:9-13
15 Baroni GS, D'Ambrosio L, Curto P, Casini A, Mancini R, Jezequel AM,Benedetti A. Interferon gamma decreases
hepatic stellate cell activation andextracellular matrix deposition in rat liver fibrosis. Hepatology 1996;23:1189-1199
16 Shibata N, Watanabe T, Okitsu T, Sakaguchi M, Takesue M, Kunieda T,Omoto K, Yamamoto S, Tanaka N,Kobayashi N. Establishment of animmortalized human hepatic stellate cell line to develop antifibrotictherapies.
, http://www.100md.com
Cell Transplant 2003;12:499-507
17 Saile B, Eisenbach C, Dudas J, El-Armouche H, Ramadori G.Interferon-gamma acts proapoptotic on hepatic stellate
cells(HSC)and abrogates theantiapoptotic effect of interferon-alpha by an HSP70-dependant pathway.
Eur J Cell Biol 2004;83:469-476
编辑 张海宁, 百拇医药( 饶慧瑛,魏 来)
