大鼠非酒精性脂肪性肝炎肝组织MMP-13及TIMP-1表达变化与肝纤维化的关系
基质金属蛋白酶-13;基质金属蛋白酶抑制物-1;非酒精性脂肪性肝炎;逆转录聚合酶链反应;肝纤维化,张洁,陈晓宇,彭延申,李继强,项目负责人,:,ExpressionofMMP-13andTIMP-1inratliverwithnonalcoholicsteatohepa
张洁,上海第二医科大学附属仁济医院检验科 上海市 200127陈晓宇,彭延申,李继强, 上海市消化疾病研究所 上海市 200001
张洁,女, 1965-12-06生, 江苏江阴人,汉族,1989年上海第二医科大学毕业,主管技师, 主要从事临床生化检验工作.
上海市自然科学基金资助项目,No. 03ZR14045
项目负责人:李继强, 200001, 上海市山东中路145号, 上海市消化疾病研究所.ljqzh@yahoo.com.cn
电话:021-63260930-2001
收稿日期:2004-11-18 接受日期: 2004-12-08
Expression of MMP-13 and TIMP-1 in rat liver withnonalcoholic steatohepatitis
Jie Zhang, Xiao-Yu Chen, Yan-Shen Li, Ji-Qiang Li
Zhang Jie,Department of Clinical Laboratory, Renji Hospital, Shanghai Second MedicalUniversity, Shanghai 200127, China
Xiao-Yu Chen, Yan-Shen Li, Ji-Qiang Li, Shanghai Institute ofDigestive Diseases, Shanghai 200001, China
Supported by the Natural Science Foundation of Shanghai, No.03ZR14045
Correspondence to: Ji-Qiang Li, Shanghai Institute of DigestiveDiseases. Shanghai 200001, China. ljqzh@yahoo.com.cn
Received: 2004-11-18 Accepted:2004-12-08
Abstract
AIM: To investigate the implications of matrix metallopro-teinase-13(MMP-13) and tissue inhibitors of metallopro-teinase1 (TIMP-1) in thedevelopment of liver fibrosis in experimental nonalcoholic steatohepatitis(NASH). ......
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